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1-(3,6-二溴-9h-咔唑-9-基)-3-(二甲基氨基)-2-丙醇

用途

Wiskottatin是神经元Wiskott-Aldrich综合征蛋白(N-WASP)介导的肌动蛋白聚合的有效和选择性抑制剂。Wiskostatin会导致细胞ATP水平迅速、深刻和不可逆转的下降[1]。

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名称

[ CAS 号 ]:
253449-04-6

[ 中文名 ]:
1-(3,6-二溴-9h-咔唑-9-基)-3-(二甲基氨基)-2-丙醇

[ 英文名 ]:
Wiskostatin

[英文别名 ]:

Wiskostatin

生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞骨架 >> Arp2/3复合物

研究领域 >> 神经疾病

[参考文献]

[1]. Guerriero CJ, et al. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am J Physiol Cell Physiol. 2007;292(4):C1562-C1566.

物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
320.2±22.0 °C at 760 mmHg

[ 熔点 ]:
153-155ºC

[ 分子式 ]:
C₁₇H₁₈Br₂N₂O

[ 分子量 ]:
426.146

[ 闪点 ]:
147.4±22.3 °C

[ 精确质量 ]:
423.978577

[ PSA ]:
28.40000

[ LogP ]:
5.65

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.657

[ 储存条件 ]:
2-8°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H413

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
Xi: Irritant;C: Corrosive;

[ 危险品运输编码 ]:
UN3259

[ 海关编码 ]:
2933990090

海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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