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异丙威

异丙威用途

Isoprocarb 是一种氨基甲酸酯杀虫剂,广泛用于控制稻田虱和叶蝉。Isoprocarb 也是一种 AChE 抑制剂。

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异丙威名称

[ CAS 号 ]:
2631-40-5

[ 中文名 ]:
异丙威

[ 英文名 ]:
MIPC

[中文别名 ]:

[英文别名 ]:

Mipsin
oms-32
o-Cumenyl methylcarbamate
Ppc 3
2-(Propan-2-yl)phenyl methylcarbamate
MFCD00053078
o-Isopropylphenyl N-methylcarbamate
2-Isopropylphenyl methylcarbamate
2-(1-methylethyl)phenyl N-methylcarbamate
2-i-propylphenyl N-methylcarbamate

异丙威生物活性

[ 描述 ]:

Isoprocarb 是一种氨基甲酸酯杀虫剂,广泛用于控制稻田虱和叶蝉。Isoprocarb 也是一种 AChE 抑制剂。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[参考文献]

[1]. Chao Wang, et al. Responses of AChE and GST activities to insecticide coexposure in Carassius auratus. Environ Toxicol. 2012 Jan;27(1):50-7.

异丙威物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
264.9±23.0 °C at 760 mmHg

[ 熔点 ]:
96-97ºC

[ 分子式 ]:
C₁₁H₁₅NO₂

[ 分子量 ]:
193.242

[ 闪点 ]:
114.0±22.6 °C

[ 精确质量 ]:
193.110275

[ PSA ]:
38.33000

[ LogP ]:
2.51

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.507

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

异丙威MSDS

异丙威毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FB7880000

CHEMICAL NAME :: Carbamic acid, methyl-, o-cumenyl ester

CAS REGISTRY NUMBER :: 2631-40-5

BEILSTEIN REFERENCE NO. :: 1875020

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C11-H15-N-O2

MOLECULAR WEIGHT :: 193.27

WISWESSER LINE NOTATION :: 1YR BOVM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C206,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,504,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,504,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 142 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 44,241,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 44,241,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,78,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,78,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (40),32,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 56200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

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异丙威安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn;N

[ 风险声明 (欧洲) ]:
R22;R67

[ 安全声明 (欧洲) ]:
S60-S61-S62-S33-S16-S9

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ RTECS号 ]:
FB7880000

[ 海关编码 ]:
2924199090

异丙威合成路线

异丙威上下游产品

异丙威上游产品

异丙威下游产品

异丙威制备

其他氨基甲酸酯类农药（例如西维因、速灭威）有相似之处，工业上生产主要有热法、冷法两种。热法即甲基异氰酸酯法，先由甲胺与光气气相反应得到甲氨甲酰氯，然后在溶剂四氯化碳中热分解，脱氯化氢生成甲基异氰酸酯。甲基异氰酸酯与邻异丙基酚反应即生成叶蝉散。1.甲基异氰酸酯的制备甲胺与光气以1：1.3（摩尔比）配合，甲胺预热至240℃，光气预热至150℃，混合后进入酰氯合成管，合成产物进入酰氯釜与釜内四氯化碳形15-20%的溶液，加热，使四氯化碳-甲氨甲酰氯溶液保持沸腾，蒸出含异氰酸酯、氯化氢、四氯化碳的蒸气，进入酰氯冷凝器，冷凝液进入中间釜加热蒸出混合物再经冷凝脱去一部分氯化氢，冷凝液再次蒸发脱除氯化氢后进入粗酯粗馏塔，蒸馏得到异氰酸酯粗品。粗品再经脱除光气，粗馏得到粗甲基异氰酸酯产品。粗品再经脱降光气，粗馏得到粗甲基异氰酸酯产品，含量一般在99%以上。收率85.5%。2.叶蝉散制备反邻异丙基酚加入搪玻璃反应釜，再加入三乙胺，搅拌后在常温下滴加甲基异氰酸酯，在1h内加完，靠反应热自动升温。加完后，稍再加热使温度达到100℃，保温反应0.5h。反应结束后放入结片机，结片后的产品即叶蝉散，平均含量98.5%，平均收率近98%。冷法的反应顺序正好相反，先使邻异丙基酚光气化，生成氯甲酸酯，再与一甲胺反应得到叶蝉散。光气化反应需要冷冻条件，故称冷法。每吨产品消耗邻异丙基酚730kg，40%甲胺400kg。

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异丙威海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

异丙威文献

Analysis of carbofuran, carbosulfan, isoprocarb, 3-hydroxycarbofuran, and 3-ketocarbofuran by micellar electrokinetic chromatography.

J. Sep. Sci. 35(10-11) , 1359-64, (2012)

We developed an analytical method for the detection and quantitation of five pesticides and some of their metabolites - 3-hydroxycarbofuran, 3-ketocarbofuran, carbofuran, carbosulfan, and isoprocarb -...

Comparison of greenhouse and field degradation behaviour of isoprocarb, hexaflumuron and difenoconazole in Perilla frutescens.

Bull. Environ. Contam. Toxicol. 89(4) , 868-72, (2012)

Isoprocarb, hexaflumuron and difenoconazole were used in Perilla frutescens at 600, 60 and 75 g a.i./ha respectively. High performance liquid chromatography-tandem mass spectrometry was used for resid...

Prussian blue mediated amplification combined with signal enhancement of ordered mesoporous carbon for ultrasensitive and specific quantification of metolcarb by a three-dimensional molecularly imprinted electrochemical sensor.

Biosens. Bioelectron. 64 , 247-54, (2014)

In this work, we presented a three-dimensional (3D) molecularly imprinted electrochemical sensor (MIECS) with novel strategy for ultrasensitive and specific quantification of metolcarb based on prussi...

更多文献

异丙威

异丙威用途

异丙威名称

异丙威生物活性

异丙威物理化学性质

异丙威MSDS

详细MSDS(安全技术说明书)

异丙威毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

异丙威安全信息

异丙威合成路线

详细合成路线

异丙威上下游产品

异丙威上游产品

异丙威下游产品

异丙威制备

异丙威海关

异丙威文献

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