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HT-2 毒素

HT-2 毒素用途

HT-2 Toxin是T-2 toxin的活性去乙酰化代谢物。HT-2 Toxin抑制植物蛋白合成和细胞增殖。

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HT-2 毒素名称

[ CAS 号 ]:
26934-87-2

[ 中文名 ]:
HT-2 毒素

[ 英文名 ]:
ht-2 toxin

[英文别名 ]:

HT-2
T-2,Toxin analog
valerate
Toxin HT 2
Pentanoic acid anion
Mycotoxin HT 2
ht-2toxin solution

HT-2 毒素生物活性

[ 描述 ]:

HT-2 Toxin是T-2 toxin的活性去乙酰化代谢物。HT-2 Toxin抑制植物蛋白合成和细胞增殖。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Nathanail, A.V., et al. Metabolism of the fusarium mycotoxins T-2 toxin and HT-2 toxin in wheat J.Agric.Food Chem 63(35), 7862-7872 (2015).

[2]. Berthiller, F., et al. Masked mycotoxins: A review Mol.Nutr.Food Res. 57, 165-186 (2013).

HT-2 毒素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
537.1±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₃₂O₈

[ 分子量 ]:
424.485

[ 闪点 ]:
179.8±23.6 °C

[ 精确质量 ]:
424.209717

[ PSA ]:
114.82000

[ LogP ]:
2.27

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
−20°C

HT-2 毒素MSDS

详细MSDS(安全技术说明书)

HT-2 毒素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD0050000

CHEMICAL NAME :: Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-, 15-acetate, 8-isovalerate

CAS REGISTRY NUMBER :: 26934-87-2

LAST UPDATED :: 199306

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C22-H32-O8

MOLECULAR WEIGHT :: 424.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,923,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Behavioral - ataxia

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,923,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,191,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 46,2613,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Blood - hemorrhage

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 7220 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Behavioral - muscle weakness Behavioral - food intake (animal)

REFERENCE :: AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976- Volume(issue)/page/year: 35,636,1978

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HT-2 毒素安全信息

[ 危害码 (欧洲) ]:
T+,T,Xn,F

[ 风险声明 (欧洲) ]:
26/27/28-36/37/38-36-20/21/22-11

[ 安全声明 (欧洲) ]:
22-26-36/37/39-45-36/37-16

[ 危险品运输编码 ]:
UN 3462 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
YD0050000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

HT-2 毒素

HT-2 毒素用途

HT-2 毒素名称

HT-2 毒素生物活性

HT-2 毒素物理化学性质

HT-2 毒素MSDS

详细MSDS(安全技术说明书)

HT-2 毒素毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

HT-2 毒素安全信息

HT-2 毒素合成路线

详细合成路线

HT-2 毒素上下游产品

HT-2 毒素上游产品

HT-2 毒素下游产品

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