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丙甲菌素

丙甲菌素用途

Alamethicin 是从Trichoderma viride 中分离得到的一种通道形成抗生素肽,可诱导电压门控电导。

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丙甲菌素名称

[ CAS 号 ]:
27061-78-5

[ 中文名 ]:
丙甲菌素

[ 英文名 ]:
Alamethicin

[英文别名 ]:

alamethicin from trichoderma viride
MFCD00151517
ALAMETHICINRESEARCH GRADE

丙甲菌素生物活性

[ 描述 ]:

Alamethicin 是从Trichoderma viride 中分离得到的一种通道形成抗生素肽,可诱导电压门控电导。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Rindfleisch H, et al. Biosynthesis of alamethicin. FEBS Lett. 1976 Mar 1;62(3):276-80.

[2]. Olga S.Ostroumova, et al. Chapter Six - Modifiers of Membrane Dipole Potentials as Tools for Investigating Ion Channel Formation and Functioning. International Review of Cell and Molecular Biology Volume 315, 2015, Pages 245-297.

丙甲菌素物理化学性质

[ 熔点 ]:
255-270ºC

[ 分子式 ]:
C₉₂H₁₅₀N₂₂O₂₅

[ 分子量 ]:
1964.31000

[ 精确质量 ]:
1963.11000

[ PSA ]:
708.13000

[ LogP ]:
3.96740

[ 外观性状 ]:
固体

[ 储存条件 ]:
-20°C

丙甲菌素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
R25

[ 危险品运输编码 ]:
UN 3462 6

丙甲菌素文献

The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels.

Biochim. Biophys. Acta 1778(12) , 2814-22, (2008)

We examined the permeabilization of lipid bilayers by the beta-sheet, cyclic antimicrobial decapeptide gramicidin S (GS) in phospholipid bilayers formed either by mixtures of zwitterionic diphytanoylp...

Interaction of the antibiotic minocycline with liver mitochondria - role of membrane permeabilization in the impairment of respiration.

FEBS J. 280(24) , 6589-99, (2013)

Several studies have proposed that the antibiotic minocycline (MC) has cytoprotective activities. Nevertheless, when cells have been exposed to MC at micromolar concentrations, detrimental effects hav...

ATP serves as an endogenous inhibitor of UDP-glucuronosyltransferase (UGT): a new insight into the latency of UGT.

Drug Metab. Dispos. 40(11) , 2081-9, (2012)

We have suggested that adenine-related compounds are allosteric inhibitors of UGT in rat liver microsomes (RLM) treated with detergent. To clarify whether the same occurs with a pore-forming peptide, ...

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