苯并呋喃
苯并呋喃用途
苯并呋喃名称
[ CAS 号 ]:
271-89-6
[ 中文名 ]:
氧茚
[ 英文名 ]:
Coumarone
[中文别名 ]:
[英文别名 ]:
- Coumarone
- 4-Chlorosulfonyl-2,1,3-benzothiadiazole
- MFCD00005847
- 2,1,3-benzothiadiazole-4-sulfonylchloride
- Benzo<a>pyrene
- Benzo-2,1,3-thiadiazole-4-sulphonyl chloride
- 2,3-Benzofuran
- EINECS 205-982-6
- 2,1,3-benzothiadiazol-4-sulfonyl chloride
- 1-Benzofuran
苯并呋喃物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
174.0±0.0 °C at 760 mmHg
[ 熔点 ]:
-18ºC
[ 分子式 ]:
C8H6O
[ 分子量 ]:
118.133
[ 闪点 ]:
56.1±0.0 °C
[ 精确质量 ]:
118.041862
[ PSA ]:
13.14000
[ LogP ]:
2.67
[ 外观性状 ]:
透明至略绿色液体
[ 蒸汽压 ]:
1.7±0.3 mmHg at 25°C
[ 折射率 ]:
1.600
[ 储存条件 ]:
库房通风低温干燥,轻装轻卸、与氧化剂和酸类分开存放
[ 水溶解性 ]:
insoluble
苯并呋喃MSDS
苯并呋喃毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DF6423800
- CHEMICAL NAME :
- Benzofuran
- CAS REGISTRY NUMBER :
- 271-89-6
- BEILSTEIN REFERENCE NO. :
- 0107704
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C8-H6-O
- MOLECULAR WEIGHT :
- 118.14
- WISWESSER LINE NOTATION :
- T56 BOJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7 gm/kg/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16250 mg/kg/13W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in both tubules and glomeruli
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32500 mg/kg/13W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 437 mg/kg/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 61800 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30900 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 199 mg/L
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-370,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3271 No. of Facilities: 40 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 111 (estimated)
苯并呋喃安全信息
[ 符号 ]:
GHS02, GHS08
[ 信号词 ]:
Warning
[ 危害声明 ]:
H226-H351-H412
[ 警示性声明 ]:
P273-P281
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R10;R40
[ 安全声明 (欧洲) ]:
S36/37-S16
[ 危险品运输编码 ]:
UN 1993 3/PG 3
[ WGK德国 ]:
3
[ RTECS号 ]:
DF6423800
[ 包装等级 ]:
III
[ 危险类别 ]:
3
[ 海关编码 ]:
29329900
苯并呋喃合成路线
苯并呋喃上下游产品
苯并呋喃上游产品
苯并呋喃下游产品
苯并呋喃制备
1. 由水杨醛与一氯乙酸反应制得邻甲酰苯氧乙酸，再经闭环而得。将香豆素加热至860℃，生成气态产物和粘稠物，将粘稠物分馏，其中172-174℃馏分为苯并呋喃。苯并呋喃也可从煤焦油分离得到。将重苯和轻油馏分混合，蒸馏切取160-215馏分，其中含有苯并呋喃约4%。但通常利用这一馏分生产茚-古马隆树脂，而不需提出纯品。
2. 从煤焦油中分离得到。通过加热苯氧乙醛和氯化锌、乙酸制备。
苯并呋喃海关
[ 海关编码 ]: 2932999099
[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
苯并呋喃文献
Bioorg. Med. Chem. 22(23) , 6655-64, (2015)
Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by e...
Cyclooxygenase 2 inhibitor celecoxib inhibits glutamate release by attenuating the PGE2/EP2 pathway in rat cerebral cortex endings.J. Pharmacol. Exp. Ther. 351(1) , 134-45, (2014)
The excitotoxicity caused by excessive glutamate is a critical element in the neuropathology of acute and chronic brain disorders. Therefore, inhibition of glutamate release is a potentially valuable ...
Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.Biochim. Biophys. Acta 1838(10) , 2484-91, (2014)
CLC-K chloride channels play a crucial role in kidney physiology and genetic mutations, affecting their function are responsible for severe renal salt loss in humans. Thus, compounds that selectively ...
相关化工产品/化学物质：
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公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：苯并呋喃
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥188.0/100g
￥98.0/25g
联系人：刘佳
产品详情：苯并呋喃
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥35.0/5g
￥574.0/500g
￥66.0/25g
￥329.0/250g
联系人：阿拉丁
产品详情：苯并呋喃
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相关化合物
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