蝇蕈醇

蝇蕈醇用途

毒蕈碱(Agarin)是一种精神活性异恶唑,是一种选择性神经递质GABA激动剂。毒蕈碱在高亲和力和低亲和力位点(Kd分别为10和270 nM)结合GABAA,以200 nM的EC50值刺激氯离子流出。毒蕈碱通过血脑屏障(BBB)并具有破坏记忆的作用[1]。

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蝇蕈醇名称

[ CAS 号 ]:
2763-96-4

[ 中文名 ]:
蝇蕈醇

[ 英文名 ]:
Muscimol

[中文别名 ]:

5-(氨甲基)-3-羟基-异恶唑

[英文别名 ]:

5-(aminomethyl)-1,2-oxazol-3-one
5-Aminomethyl-3-hydroxy-isoxazol
PANTHERINE
5-(Aminomethyl)isoxazol-3(2H)-one
Agarine
5-Aminomethyl-3-hydroxyisoxazole
UNII:D5M179TY2E
3(2H)-Isoxazolone, 5-(aminomethyl)-
3-Hydroxy-5-aminomethylisoxazole
MFCD00057894

蝇蕈醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[参考文献]

[1]. S M Dunn, et al. Reconstitution of purified GABAA receptors: ligand binding and chloride transporting properties. Biochemistry. 1994 Jan 25;33(3):755-63.

[2]. Donna R Ramirez, et al. The role of the GABA(A) agonist muscimol on memory performance: reward contingencies determine the nature of the deficit. Neurobiol Learn Mem. 2005 Nov;84(3):184-91.

[3]. M Irifune, et al. Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline. Br J Anaesth. 1999 Oct;83(4):665-7.

蝇蕈醇物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
325.0±27.0 °C at 760 mmHg

[ 熔点 ]:
175-176ºC

[ 分子式 ]:
C₄H₆N₂O₂

[ 分子量 ]:
114.103

[ 闪点 ]:
150.4±23.7 °C

[ 精确质量 ]:
114.042931

[ PSA ]:
72.28000

[ LogP ]:
-0.93

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.556

[ 储存条件 ]:
库房通风低温干燥

蝇蕈醇MSDS

蝇蕈醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY3325000

CHEMICAL NAME :: 3-Isoxazolol, 5-(aminomethyl)-

CAS REGISTRY NUMBER :: 2763-96-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H6-N2-O2

MOLECULAR WEIGHT :: 114.12

WISWESSER LINE NOTATION :: T5NOJ C1Z EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human

DOSE/DURATION :: 109 ug/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,311,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,311,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,311,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0000338

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,311,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 ug/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,311,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5620 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#11824

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,311,1968

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蝇蕈醇安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
25

[ 安全声明 (欧洲) ]:
S22;S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 1544 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
NY3345000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2934999090

蝇蕈醇合成路线

蝇蕈醇上下游产品

蝇蕈醇上游产品

蝇蕈醇下游产品

蝇蕈醇海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

蝇蕈醇文献

Frontostriatal systems comprising connections between ventral medial prefrontal cortex and nucleus accumbens subregions differentially regulate motor impulse control in rats.

Psychopharmacol. Ser. 232(7) , 1291-302, (2015)

Deficits in impulse control are prevalent in several neuropsychiatric disorders that are based on impaired frontostriatal communication. The ventral medial prefrontal cortex (vmPFC) and the nucleus ac...

GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters.

Nat. Commun. 6 , 7879, (2015)

The non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant growth. Until now it was not known whether...

Optogenetic stimulation of mPFC pyramidal neurons as a conditioned stimulus supports associative learning in rats.

Sci. Rep. 5 , 10065, (2015)

It is generally accepted that the associative learning occurs when a behaviorally neutral conditioned stimulus (CS) is paired with an aversive unconditioned stimulus (US) in close temporal proximity. ...

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蝇蕈醇