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亚油酰甘氨酸

亚油酰甘氨酸用途

亚油酸甘氨酸是一种改性多不饱和脂肪酸。亚油酸甘氨酸对爪蟾卵母细胞中表达的人KCNQ1/KCNE1(hKCNQ1/hKCNE1)通道具有激活作用[1]。

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亚油酰甘氨酸名称

[ CAS 号 ]:
2764-03-6

[ 中文名 ]:
亚油酰甘氨酸

[ 英文名 ]:
N-[(9Z,12Z)-9,12-Octadecadienoyl]glycine

[英文别名 ]:

Glycine-linoleamide
N-[(9Z,12Z)-9,12-Octadecadienoyl]glycine
N-linoleoyl glycine
N-[(9Z,12Z)-octadeca-9,12-dienoyl]glycine
linoleyl glycine
Linoleoyl-glycin

亚油酰甘氨酸生物活性

[ 描述 ]:

亚油酸甘氨酸是一种改性多不饱和脂肪酸。亚油酸甘氨酸对爪蟾卵母细胞中表达的人KCNQ1/KCNE1(hKCNQ1/hKCNE1)通道具有激活作用[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> 钾通道

[参考文献]

[1]. Skarsfeldt MA, et al. Polyunsaturated fatty acid-derived IKs channel activators shorten the QT interval ex-vivo and in-vivo. Acta Physiol (Oxf). 2020;229(4):e13471.

亚油酰甘氨酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
530.7±43.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₅NO₃

[ 分子量 ]:
337.497

[ 闪点 ]:
274.8±28.2 °C

[ 精确质量 ]:
337.261688

[ PSA ]:
66.40000

[ LogP ]:
6.05

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.489

[ 储存条件 ]:
-20°C

亚油酰甘氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0596320

CHEMICAL NAME :: Glycine, N-linoleoyl-

CAS REGISTRY NUMBER :: 2764-03-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H35-N-O3

MOLECULAR WEIGHT :: 337.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 44,145,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 44,145,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 44,145,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 44,145,1986

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亚油酰甘氨酸安全信息

[ 海关编码 ]:
2924199090

亚油酰甘氨酸合成路线

详细合成路线

亚油酰甘氨酸上下游产品

亚油酰甘氨酸上游产品

亚油酰甘氨酸下游产品

亚油酰甘氨酸海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%