甲醇(6 -乙酰吗啡)
甲醇(6 -乙酰吗啡)名称
甲醇(6 -乙酰吗啡)物理化学性质
[ 密度 ]:
1.38g/cm3
[ 沸点 ]:
470.2ºC at 760mmHg
[ 熔点 ]:
184-189ºC
[ 分子式 ]:
C19H21NO4
[ 分子量 ]:
327.37400
[ 闪点 ]:
238.2ºC
[ 精确质量 ]:
327.14700
[ PSA ]:
59.00000
[ LogP ]:
1.70680
[ 蒸汽压 ]:
1.83E-09mmHg at 25°C
[ 折射率 ]:
1.665
[ 储存条件 ]:
库房通风低温干燥
甲醇(6 -乙酰吗啡)毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QC7814500
- CHEMICAL NAME :
- Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, 6-acetate
- CAS REGISTRY NUMBER :
- 2784-73-8
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H21-N-O4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 59 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 85,317,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 147 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 85,317,1982
甲醇(6 -乙酰吗啡)安全信息
[ 符号 ]:
GHS02, GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H302 + H312-H319-H331
[ 警示性声明 ]:
P210-P261-P280-P305 + P351 + P338-P311
[ 危害码 (欧洲) ]:
F: Flammable;Xn: Harmful;
[ 风险声明 (欧洲) ]:
11-20/21/22-36
[ 安全声明 (欧洲) ]:
16-36/37-26
[ 危险品运输编码 ]:
UN 1648 3/PG 2
甲醇(6 -乙酰吗啡)文献
Proc. Natl. Acad. Sci. U. S. A. 110(22) , 9036-41, (2013)
Heroin addiction, a chronic relapsing disorder characterized by excessive drug taking and seeking, requires constant psychotherapeutic and pharmacotherapeutic interventions to minimize the potential f...
Validation of a gas chromatography-ion trap-tandem mass spectrometry assay for the simultaneous quantification of cocaine, benzoylecgonine, cocaethylene, morphine, codeine, and 6-acetylmorphine in aqueous solution, blood, and skeletal muscle tissue.J. Anal. Toxicol. 36(1) , 1-11, (2012)
A gas chromatography-ion trap-tandem mass spectrometry method was developed and validated for the simultaneous solid-phase extraction and quantification of cocaine, benzoylecgonine, cocaethylene, morp...
Simultaneous determination of xylazine, free morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in postmortem blood by UPLC-MS-MS.J. Anal. Toxicol. 36(5) , 319-26, (2012)
Xylazine, a veterinary sedative, has been found as an adulterant of heroin in street drugs in Puerto Rico. It was found in combination with free morphine and 6-acetylmorphine, codeine, cocaine and ben...
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