甲醇(6 -乙酰吗啡)

甲醇(6 -乙酰吗啡)名称

[ CAS 号 ]:
2784-73-8

[ 中文名 ]:
甲醇(6 -乙酰吗啡)

[ 英文名 ]:
6-acetylmorphine

[英文别名 ]:

甲醇(6 -乙酰吗啡)物理化学性质

[ 密度 ]:
1.38g/cm3

[ 沸点 ]:
470.2ºC at 760mmHg

[ 熔点 ]:
184-189ºC

[ 分子式 ]:
C₁₉H₂₁NO₄

[ 分子量 ]:
327.37400

[ 闪点 ]:
238.2ºC

[ 精确质量 ]:
327.14700

[ PSA ]:
59.00000

[ LogP ]:
1.70680

[ 蒸汽压 ]:
1.83E-09mmHg at 25°C

[ 折射率 ]:
1.665

[ 储存条件 ]:
库房通风低温干燥

甲醇(6 -乙酰吗啡)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QC7814500

CHEMICAL NAME :: Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, 6-acetate

CAS REGISTRY NUMBER :: 2784-73-8

LAST UPDATED :: 199512

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H21-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 85,317,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 147 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 85,317,1982

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甲醇(6 -乙酰吗啡)安全信息

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312-H319-H331

[ 警示性声明 ]:
P210-P261-P280-P305 + P351 + P338-P311

[ 危害码 (欧洲) ]:
F: Flammable;Xn: Harmful;

[ 风险声明 (欧洲) ]:
11-20/21/22-36

[ 安全声明 (欧洲) ]:
16-36/37-26

[ 危险品运输编码 ]:
UN 1648 3/PG 2

甲醇(6 -乙酰吗啡)文献

Dynamic vaccine blocks relapse to compulsive intake of heroin.

Proc. Natl. Acad. Sci. U. S. A. 110(22) , 9036-41, (2013)

Heroin addiction, a chronic relapsing disorder characterized by excessive drug taking and seeking, requires constant psychotherapeutic and pharmacotherapeutic interventions to minimize the potential f...

Validation of a gas chromatography-ion trap-tandem mass spectrometry assay for the simultaneous quantification of cocaine, benzoylecgonine, cocaethylene, morphine, codeine, and 6-acetylmorphine in aqueous solution, blood, and skeletal muscle tissue.

J. Anal. Toxicol. 36(1) , 1-11, (2012)

A gas chromatography-ion trap-tandem mass spectrometry method was developed and validated for the simultaneous solid-phase extraction and quantification of cocaine, benzoylecgonine, cocaethylene, morp...

Simultaneous determination of xylazine, free morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in postmortem blood by UPLC-MS-MS.

J. Anal. Toxicol. 36(5) , 319-26, (2012)

Xylazine, a veterinary sedative, has been found as an adulterant of heroin in street drugs in Puerto Rico. It was found in combination with free morphine and 6-acetylmorphine, codeine, cocaine and ben...

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