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嘧啶

嘧啶用途

【用途一】
用作医药中间体、感光剂的原料等

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嘧啶名称

[ CAS 号 ]:
289-95-2

[ 中文名 ]:
嘧啶

[ 英文名 ]:
Pyrimidine

[中文别名 ]:

[英文别名 ]:

iazine
Miazine
Pyrimidin
EINECS 206-026-0
PyriMidine free base
1,3-DIAZINE
1,3-Diazin
Metadiazine
m-Diazine
Pyrimidine

嘧啶物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
122.4±9.0 °C at 760 mmHg

[ 熔点 ]:
19-22 °C(lit.)

[ 分子式 ]:
C₄H₄N₂

[ 分子量 ]:
80.088

[ 闪点 ]:
31.1±0.0 °C

[ 精确质量 ]:
80.037445

[ PSA ]:
25.78000

[ LogP ]:
-0.33

[ 外观性状 ]:
白色固体或无色液体

[ 蒸汽压 ]:
16.8±0.2 mmHg at 25°C

[ 折射率 ]:
1.503

[ 储存条件 ]:
Flammables area

[ 稳定性 ]:
Stable, but air-sensitive and hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents, carbon dioxide. Flammable.

[ 水溶解性 ]:
soluble

嘧啶MSDS

嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV6263000

CHEMICAL NAME :: Pyrimidine

CAS REGISTRY NUMBER :: 289-95-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C4-H4-N2

MOLECULAR WEIGHT :: 80.10

WISWESSER LINE NOTATION :: T6N CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 150 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7311 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

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嘧啶安全信息

[ 符号 ]:

GHS02

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R10

[ 安全声明 (欧洲) ]:
S23-S24/25-S16

[ 危险品运输编码 ]:
UN 1993 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
UV6263000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2933599090

嘧啶合成路线

嘧啶上下游产品

嘧啶上游产品

嘧啶下游产品

嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

嘧啶文献

Assessing the metabolic impact of nitrogen availability using a compartmentalized maize leaf genome-scale model.

Plant Physiol. 166(3) , 1659-74, (2014)

Maize (Zea mays) is an important C4 plant due to its widespread use as a cereal and energy crop. A second-generation genome-scale metabolic model for the maize leaf was created to capture C4 carbon fi...

Orthovanadate-Induced Vasoconstriction of Rat Mesenteric Arteries Is Mediated by Rho Kinase-Dependent Inhibition of Myosin Light Chain Phosphatase.

Biol. Pharm. Bull. 38 , 1809-16, (2015)

Orthovanadate (OVA), a protein tyrosine phosphatase inhibitor, induces vasoconstriction in a Rho kinase-dependent manner. The aim of this study was to determine the mechanism underlying OVA-induced va...

Cetuximab-induced insulin-like growth factor receptor I activation mediates cetuximab resistance in gastric cancer cells.

Mol. Med. Report. 11 , 4547-54, (2015)

Epidermal growth factor receptor (EGFR) and insulin‑like growth factor receptor‑I (IGF‑IR) are frequently overexpressed in gastric cancer cells. However, these cells are resistant to the anti‑EGFR mon...

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嘧啶