N-甲基哌嗪

N-甲基哌嗪用途

【用途一】
用于制取抗菌类药物甲哌利福霉素、抗精神病药三氟拉嗪及氧氟沙星等
【用途二】
有机合成中间体。在医药工业中用于制取抗菌素类药物甲哌利福霉素、抗精神病药三氟拉嗪等。主要用作氧氟沙星、氯氮平、西地那非、吐立抗、佐匹克隆等药物的中间体，亦可用于农药、染料、塑料等行业。
【用途三】
有机合成、制药、合成纤维等的中间体。

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N-甲基哌嗪名称

[ CAS 号 ]:
109-01-3

[ 中文名 ]:
N-甲基哌嗪

[ 英文名 ]:
methylpiperazine

[中文别名 ]:

[英文别名 ]:

Piperazine, 1-methyl-
methyl piperazine
4-Methylpiperazine
Cyclizine Related Compound A
N-METHYL-PIPERAZINE
EINECS 203-639-5
N-Methylpiperazine
PIPERAZINE,1-METHYL
N'-Methylpiperazine
1-Methyl-piperazine

N-甲基哌嗪物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
138.0±8.0 °C at 760 mmHg

[ 熔点 ]:
-6 °C

[ 分子式 ]:
C₅H₁₂N₂

[ 分子量 ]:
100.162

[ 闪点 ]:
42.2±0.0 °C

[ 精确质量 ]:
100.100044

[ PSA ]:
15.27000

[ LogP ]:
-0.18

[ 外观性状 ]:
透明无色液体

[ 蒸汽密度 ]:
3.5 (vs air)

[ 蒸汽压 ]:
6.9±0.3 mmHg at 25°C

[ 折射率 ]:
1.442

[ 储存条件 ]:
Store under Nitrogen

[ 水溶解性 ]:
soluble

N-甲基哌嗪MSDS

N-甲基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM1225000

CHEMICAL NAME :: Piperazine, 1-methyl-

CAS REGISTRY NUMBER :: 109-01-3

BEILSTEIN REFERENCE NO. :: 0102724

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C5-H12-N2

MOLECULAR WEIGHT :: 100.19

WISWESSER LINE NOTATION :: T6M DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,863,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,863,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2830 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2740 mg/m3/2H

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 11,123,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1490 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15040 mg/kg/32D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 11,123,1969

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N-甲基哌嗪安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H312-H314-H331

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R21;R34

[ 安全声明 (欧洲) ]:
S16-S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2734 8/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
TM1225000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2933599090

N-甲基哌嗪合成路线

N-甲基哌嗪上下游产品

N-甲基哌嗪上游产品

N-甲基哌嗪下游产品

N-甲基哌嗪制备

由六水哌嗪经甲基化反应而得。将六水哌嗪及盐酸加入反应锅中，加热至45℃，滴加甲酸和甲醛的混合液。加毕，在50℃左右反应2-3h，再升温回流，至二氧化碳气体不再逸出为止。冷却至80℃，加入盐酸，加热蒸酸至干。稍冷后加入甲醇，加热回流30min，趁热过滤（滤渣为哌嗪二盐酸盐）。滤液回收甲醇至尽，残液加入氢氧化钠溶液至pH=14，蒸馏，得含水甲基哌嗪。加苯加热回流带水至尽，分馏，收集132-140℃馏分，得无水甲基哌嗪。收率约50%。

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N-甲基哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-甲基哌嗪文献

Synthesis and antitumor activities of some new N1-(flavon-6-yl)amidrazone derivatives.

Arch. Pharm. (Weinheim) 347(6) , 415-22, (2014)

A new series of N1-(flavon-6-yl)amidrazones were synthesized by reacting the hydrazonoyl chloride derived from 6-aminoflavone with the appropriate sec-cyclic amines. The antitumor activities of these ...

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

Bioorg. Med. Chem. 23(9) , 2024-34, (2015)

Recently we described a novel pyranopyridine inhibitor (MBX2319) of RND-type efflux pumps of the Enterobacteriaceae. MBX2319 (3,3-dimethyl-5-cyano-8-morpholino-6-(phenethylthio)-3,4-dihydro-1H-pyrano[...

Synthesis of 1H-1,2,3-triazole linked aryl(arylamidomethyl) - dihydrofurocoumarin hybrids and analysis of their cytotoxicity.

Eur. J. Med. Chem. 100 , 119-28, (2015)

A series of 2-(4-R-triazolyl)substituted 3-oxo-2,3-dihydrofurocoumarins have been synthesized by a regioselective cycloaddition of 2-azidooreoselone 1 or 2-azido-9-[(4-methylpiperazin-1-yl)methyl]oreo...

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N-甲基哌嗪

N-甲基哌嗪用途

N-甲基哌嗪名称

N-甲基哌嗪物理化学性质

N-甲基哌嗪MSDS

详细MSDS(安全技术说明书)

N-甲基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

N-甲基哌嗪安全信息

N-甲基哌嗪合成路线

详细合成路线

N-甲基哌嗪上下游产品

N-甲基哌嗪上游产品

N-甲基哌嗪下游产品

N-甲基哌嗪制备

N-甲基哌嗪海关

N-甲基哌嗪文献

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