涛洛西酮

Toloxatone (MD 69276) 是一种可逆的单胺氧化酶 A (MAOA) 抑制剂。用作抗抑郁剂。

[ 描述 ]:

[ 相关类别 ]:

[ 靶点 ]

[参考文献]

[ 密度 ]:
1.245g/cm3

[ 沸点 ]:
358.9ºC at 760mmHg

[ 熔点 ]:
76°

[ 分子式 ]:
C₁₁H₁₃NO₃

[ 分子量 ]:
207.23

[ 闪点 ]:
170.9ºC

[ 精确质量 ]:
207.09000

[ PSA ]:
49.77000

[ LogP ]:
1.37750

[ 蒸汽压 ]:
8.9E-06mmHg at 25°C

[ 折射率 ]:
1.57

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: >10mg/mL

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

RQ2867500

CHEMICAL NAME :

2-Oxazolidinone, 5-hydroxymethyl-3-(m-tolyl)-

CAS REGISTRY NUMBER :

29218-27-7

LAST UPDATED :

199612

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C11-H13-N-O3

MOLECULAR WEIGHT :

207.25

WISWESSER LINE NOTATION :

T5NVOTJ AR C1& D1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1225 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,569,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1300 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,569,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

650 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,569,1976

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
UN 3249

[ RTECS号 ]:
RQ2867500

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2934999090

间甲基苯胺和3-羟基环氧丙烷在加热下反应，生成3-间甲苯氨基-1，2-丙二醇，在甲醇钠作用下和氯甲酸甲酯环合，得到托洛沙酮。

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO).

Drug Test. Anal. 6(7-8) , 607-13, (2014)

5-(2-Aminopropyl)indole (5-IT) is a psychoactive compound that has recently been associated with several fatal and non-fatal intoxications in a number of European countries. There are indications that...

Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells.

J. Pharmacol. Exp. Ther. 356 , 483-92, (2016)

According to the catecholaldehyde hypothesis, the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) contributes to the loss of nigrostriatal dopaminergic neurons in Parkinson's disease...

A double-blind comparison of moclobemide and toloxatone in out-patients presenting a major depressive disorder.

Psychopharmacology 106 Suppl , S118-9, (1992)

A double-blind comparison of moclobemide and toloxatone was performed in adult out-patients diagnosed as suffering from a major depressive disorder. Parallel groups of patients received moclobemide, 4...

更多文献

公司名：上海化源生化科技有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：托洛沙酮

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Toloxatone (MD 69276)

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥799.9/10mg ￥4840.9/100mg ￥1699.9/25mg ￥3089.9/50mg

联系人：阿拉丁

产品详情：涛洛西酮

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