涛洛西酮
涛洛西酮结构式
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常用名 | 涛洛西酮 | 英文名 | Toloxatone |
|---|---|---|---|---|
| CAS号 | 29218-27-7 | 分子量 | 207.23 | |
| 密度 | 1.245g/cm3 | 沸点 | 358.9ºC at 760mmHg | |
| 分子式 | C11H13NO3 | 熔点 | 76° | |
| MSDS | 中文版 美版 | 闪点 | 170.9ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO).
Drug Test. Anal. 6(7-8) , 607-13, (2014) 5-(2-Aminopropyl)indole (5-IT) is a psychoactive compound that has recently been associated with several fatal and non-fatal intoxications in a number of European countries. There are indications that acute effects may include symptoms of monoaminergic (e.g. ... |
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Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells.
J. Pharmacol. Exp. Ther. 356 , 483-92, (2016) According to the catecholaldehyde hypothesis, the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) contributes to the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Monoamine oxidase-A (MAO-A) catalyzes the conversion of i... |
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A double-blind comparison of moclobemide and toloxatone in out-patients presenting a major depressive disorder.
Psychopharmacology 106 Suppl , S118-9, (1992) A double-blind comparison of moclobemide and toloxatone was performed in adult out-patients diagnosed as suffering from a major depressive disorder. Parallel groups of patients received moclobemide, 450 mg/day (n = 135) or toloxatone, 1000 mg/day (n = 133) fo... |
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Minor and clinically non-significant interaction between toloxatone and amitriptyline.
Eur. J. Clin. Pharmacol. 44(1) , 97-9, (1993) The possibility of a pharmacokinetic interaction between amitriptyline and toloxatone (a new MAOI-A) has been studied in 17 depressed in-patients. Amitriptyline and its demethylated and hydroxylated metabolites in blood and urine were measured at steady state... |
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Effect of acute ethanol administration on toloxatone pharmacokinetics in rabbits.
Alcohol. Clin. Exp. Res. 23(5) , 885-90, (1999) The pharmacokinetics of toloxatone and ethanol were determined in plasma and cerebrospinal fluid of conscious rabbits. According to a cross-over design, rabbits (n = 5) randomly received on three separate occasions either toloxatone (5 mg/kg), ethanol (1 g/kg... |
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The deamination of noradrenaline and 5-hydroxytryptamine by rat brain and heart monoamine oxidase and their inhibition by cimoxatone, toloxatone and MD 770222.
Naunyn Schmiedebergs Arch. Pharmacol. 323(4) , 315-20, (1983) In both rat brain and heart, noradrenaline and 5-hydroxytryptamine are metabolised predominantly by monoamine oxidase-A. The Km values for 14C-noradrenaline in the rat brain and heart are 290 microM and 300 microM, respectively, whereas for 14C-5-hydroxytrypt... |
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[Comparison of the new MAO-A inhibitors moclobemide, brofaromine and toloxatone with tranylcypromine in an animal experiment: significance for clinical practice].
Psychiatr. Prax. 16 Suppl 1 , 18-24, (1989) The rat studies presented in this manuscript show that the new non-hydrazine compounds moclobemide, brofaromine and toloxatone have a profile typical of monoamine oxidase-A (MAO-A) inhibitors. These inhibitors are short-acting (16-24 h), reversible, non-hepat... |
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Debrisoquine and dextromethorphan phenotyping and antidepressant treatment.
Therapie. 46(1) , 1-3, (1991) The correlation between debrisoquine and dextromethorphan oxidation polymorphism was studied in 16 depressed in-patients. There was a close correlation between both phenotypes (r = 0.81 p less than 0.0017). During a treatment with amitriptyline during two wee... |
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Toloxatone pharmacokinetics in the plasma and cerebrospinal fluid of the rabbit.
J. Pharm. Pharmacol. 44(2) , 124-6, (1992) The pharmacokinetics of toloxatone (5 and 10 mg kg-1, i.v.) was studied in anaesthetized rabbits. There was a biexponential decline in plasma concentration with time. No differences were observed in the pharmacokinetic parameters with the increase of the dose... |
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[Acute toloxatone poisoning. Apropos of 122 cases].
Therapie. 45(2) , 139-44, (1990) Toloxatone is a new monoamine oxidase inhibitor. One hundred and twenty two cases of poisoning with this drug are reported. In this series, the minimal toxic dose was 2 g. The first symptoms appeared about one hour after ingestion. In most cases, only drowsin... |