ALFA-胸腺肽

ALFA-胸腺肽用途

Ranatensin是一种十一肽和一种Bombesin受体安哥拉化物,可以从两栖动物的皮肤中分离出来,如青蛙、琵琶蛙。Ranatesin可以维持动物血压的动态平衡,而不会与血管紧张素酰胺(HY-P2212)、缓激肽(HY-P0206)或去甲肾上腺素(HY-13715)发生交叉快速反应[1][2]。

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ALFA-胸腺肽名称

[ CAS 号 ]:
29451-71-6

[ 中文名 ]:
ALFA-胸腺肽

[ 英文名 ]:
Ranatensin

[英文别名 ]:

GLP-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
pGlu-Val-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
PGLU-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
PYR-VAL-PRO-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2

ALFA-胸腺肽生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor

[体外研究]

Ranatensin(0.3 nM；30分钟)能够刺激多种胰促分泌物诱导淀粉酶释放[1]。

[体内研究]

Ranatesin(10-50μg/mL,0.1-1mL；静脉注射; 单剂量) 会增加狗和兔子的血压,表明其具有直接的外周血管收缩作用[2]。 Ranatesin(10-50μg/mL,0.1-1mL；静脉注射; 单剂量) 也能降低猴子的血压,与 Eledoisin(HY-P0006)一样有效。它对血管平滑肌有直接的外周作用[2]。 Ranatesin(10-50μg/mL,0.005-0.1 mL；静脉注射; 单剂量) 根据大鼠血压的基础水平具有可变的作用,在高水平时显示出降压效果,在低水平时升高血压,产生这一变化的可能原因是外周交感神经末梢释放去甲肾上腺素[2]。

[参考文献]

[1]. Jensen RT, et al. A synthetic peptide that is a bombesin receptor antagonist. Nature. 1984 May 3-9;309(5963):61-3.

[2]. Geller RG, et al. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16.

ALFA-胸腺肽物理化学性质

[ 密度 ]:
1.326 g/cm3

[ 沸点 ]:
1790.5ºC at 760 mmHg

[ 分子式 ]:
C₆₁H₈₄N₁₆O₁₃S

[ 分子量 ]:
1281.48000

[ 闪点 ]:
1036.6ºC

[ 精确质量 ]:
1280.61000

[ PSA ]:
467.26000

[ LogP ]:
3.20430

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.607

[ 储存条件 ]:
−20°C

ALFA-胸腺肽MSDS

详细MSDS(安全技术说明书)

ALFA-胸腺肽安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

ALFA-胸腺肽文献

Molecular biology of bombesin-like peptides. Comparison of cDNAs encoding human gastrin-releasing peptide, human neuromedin B, and amphibian ranatensin.

Ann. N. Y. Acad. Sci. 547 , 10-20, (1988)

Bombesin-related peptides induce calcium mobilization in a subset of human small cell lung cancer cell lines.

J. Biol. Chem. 262(34) , 16456-60, (1987)

To examine the biochemical basis for growth factor-induced responses in human lung cancer cells, we used the quin2 technique to study the effect of the amphibian peptide bombesin and its congeners inc...

Identification of the C-terminal amino acid amides by carboxypeptidase Y digestion and fast atom bombardment mass spectrometry.

Biochem. Mol. Biol. Int. 34(5) , 897-907, (1994)

The combination method of carboxypeptidase Y digestion and fast atom bombardment (FAB) mass spectrometry is described for the identification of C-terminal amino acid amides in peptides. Carboxypeptida...

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