地帕明

地帕明用途

Depramine(GP 31406)是一种具有药理活性的三环类抗抑郁药。Depramine抑制乙酰胆碱酯酶、Mg2+-ATP酶和Na+/K+ATP酶活性[1][2]。

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地帕明名称

[ CAS 号 ]:
303-54-8

[ 中文名 ]:
地帕明

[ 英文名 ]:
Depramine

[英文别名 ]:

(3-dibenzo[b,f]azepin-5-yl-propyl)-dimethyl-amine
Depramine
Depramina [INN-Spanish]
5-(3-(Dimethylamino)propyl)-5H-dibenz(b,f)azepine
10,11-Dehydroimipramine
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)
Depraminum [INN-Latin]
5-(8-Dimethylaminopropyl)-iminostilben
Balipramine
5-(3'-Dimethyl-amino-propyl)-5H-dibenz<b,f>azepin

地帕明生物活性

[ 描述 ]:

Depramine(GP 31406)是一种具有药理活性的三环类抗抑郁药。Depramine抑制乙酰胆碱酯酶、Mg2+-ATP酶和Na+/K+ATP酶活性[1][2]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[ 靶点 ]

Acetylcholinesterase (AChE), Mg2+-ATPase, Na+/K+ ATPase[1]

[参考文献]

[1]. Caratsch CG, et al. Tricyclic antidepressants: action on synaptosomal acetylcholinesterase and ATPase in the brain of guinea pigs and subcellular distribution. Neuropharmacology. 1973 Jun;12(6):563-75.

地帕明物理化学性质

[ 密度 ]:
1.06g/cm3

[ 沸点 ]:
413.9ºC at 760mmHg

[ 分子式 ]:
C₁₉H₂₂N₂

[ 分子量 ]:
278.39

[ 闪点 ]:
185.9ºC

[ 精确质量 ]:
278.17800

[ PSA ]:
6.48000

[ LogP ]:
4.32520

[ 折射率 ]:
1.589

地帕明毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO1480000

CHEMICAL NAME :: 5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 303-54-8

BEILSTEIN REFERENCE NO. :: 1319717

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H22-N2

MOLECULAR WEIGHT :: 278.43

WISWESSER LINE NOTATION :: T C676 BNJ B3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

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地帕明安全信息

[ 海关编码 ]:
2933990090

地帕明合成路线

详细合成路线

地帕明上下游产品

地帕明上游产品

地帕明下游产品

地帕明海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

地帕明