N'-benzylpivalohydrazide

N'-benzylpivalohydrazide用途

吡戊酰苯肼(吡哌嗪)是一种有效的单胺氧化酶(MAO)抑制剂。吡戊酰苯肼降低正常大鼠的软骨生长。新戊酰苯肼可用于抑郁症研究[1]。

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N'-benzylpivalohydrazide名称

[ CAS 号 ]:
306-19-4

[ 英文名 ]:
N'-benzylpivalohydrazide

[英文别名 ]:

Tersavide
Pivazid
N'-benzyl-2,2-dimethyl-propanehydrazide
N'-benzylpivalohydrazide
Betamezide
N-Benzyl pivalhydrazide
Pivalylbenzhydrazine
1-Trimethylacetyl-2-benzyl-hydrazin
Tersavid
PIVHYDRAZINE

N'-benzylpivalohydrazide生物活性

[ 描述 ]:

吡戊酰苯肼(吡哌嗪)是一种有效的单胺氧化酶(MAO)抑制剂。吡戊酰苯肼降低正常大鼠的软骨生长。新戊酰苯肼可用于抑郁症研究[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[体内研究]

吡戊酰苯肼(吡哌嗪；5 mg/kg；i.p.；每日,持续5天；未成熟雌性大鼠)抑制骨骺软骨的生长[1]。动物模型：未成年雌性大鼠(40 g,3-4周龄)[1]剂量：5 mg/kg给药：腹膜内注射；结果：抑制骨骺软骨的生长

N'-benzylpivalohydrazide物理化学性质

[ 密度 ]:
1.015g/cm3

[ 沸点 ]:
296.1ºC at 760mmHg

[ 分子式 ]:
C₁₂H₁₈N₂O

[ 分子量 ]:
206.28400

[ 闪点 ]:
105.6ºC

[ 精确质量 ]:
206.14200

[ PSA ]:
41.13000

[ LogP ]:
2.63530

[ 折射率 ]:
1.517

N'-benzylpivalohydrazide毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TO7874000

CHEMICAL NAME :: Pivalic acid, 2-benzylhydrazide

CAS REGISTRY NUMBER :: 306-19-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H18-N2-O

MOLECULAR WEIGHT :: 206.32

WISWESSER LINE NOTATION :: 1X1&1&VMM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 10 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,343,1968

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N'-benzylpivalohydrazide安全信息

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2928000090

N'-benzylpivalohydrazide海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%