1,2,4-丁三醇

1,2,4-丁三醇用途

【用途一】
用途与甘油相似，可用作湿润剂、溶剂和生产医药、炸药的中间体
【用途二】
与甘油相似，可作溶剂，湿润剂和医药、炸药的中间体。但由于在价格上难以与甘油竞争，影响了这一产品的发展。
【用途三】
多种药物制备的关键中间体烟草助剂，减少焦油成分的危害照相显影液组分，增加色彩度和粘着力高级墨水的防干剂高级服装的表面处理剂陶瓷加工助剂高分子材料的交联剂特殊用途

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1,2,4-丁三醇名称

[ CAS 号 ]:
3068-00-6

[ 中文名 ]:
1,2,4-丁三醇

[ 英文名 ]:
Q2YQ1Q

[中文别名 ]:

1,2,4-三羟基丁烷,丁三醇

[英文别名 ]:

(+/-)-butan-1,2,4-triol
2-Deoxyerythritol
triol124
1,2,4-Butanetriol
1,2,4-Butanetriol 1,2,4-Butanetriol
butane-1,2,4-triol
1,2,4-BUTANTRIOL
4-Butanetriol
Butanetriol
MFCD00002929

1,2,4-丁三醇物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
303.9±0.0 °C at 760 mmHg

[ 熔点 ]:
-20ºC

[ 分子式 ]:
C₄H₁₀O₃

[ 分子量 ]:
106.120

[ 闪点 ]:
153.9±16.4 °C

[ 精确质量 ]:
106.062996

[ PSA ]:
60.69000

[ LogP ]:
-2.09

[ 外观性状 ]:
透明黄色至略褐色液体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.487

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
水溶性：完全混溶；混溶：乙醇

1,2,4-丁三醇MSDS

1,2,4-丁三醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7176000

CHEMICAL NAME :: 1,2,4-Butanetriol

CAS REGISTRY NUMBER :: 3068-00-6

BEILSTEIN REFERENCE NO. :: 1733456

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H10-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 93,152,1953

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1,2,4-丁三醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
EK7176000

[ 海关编码 ]:
2905499000

1,2,4-丁三醇合成路线

1,2,4-丁三醇上下游产品

1,2,4-丁三醇上游产品

1,2,4-丁三醇下游产品

1,2,4-丁三醇制备

由1,4-丁炔二醇以汞盐催化水合为1,4-二羟基-2-丁酮，再在硫化钼或雷尼镍存在下加氢而得。1.水合将丁炔二醇和水加入反应锅，搅拌下加入硫酸汞，再慢慢加入硫酸，于30-35℃反应60h。反应结束后用碳酸钙中和至pH7，搅拌半小时。滤去硫酸钙沉淀，水洗滤渣，洗滤液合并浓缩，得1,4-二羟基-2-丁酮（浓缩液）。2.加氢将1,4-二羟基-2-丁酮浓缩液加入高压釜，加乙醇和雷尼镍，密闭，置换空气后，在60℃、3-4.9MPa加氢反应，当吸氢变慢后，升温至100℃继续反应到不再吸氢。冷却至50℃以下出料，过滤。滤液常压回收乙醇后，减压蒸馏，收集155-165℃（0.133-0.267kPa），馏分，即得1,2,4-丁三醇。

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1,2,4-丁三醇海关

[ 海关编码 ]: 2905499000

[ 中文概述 ]:
2905499000 其他多元醇。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905499000 other polyhydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1,2,4-丁三醇文献

Cellular uptake kinetics of bortezomib in relation to efficacy in myeloma cells and the influence of drug transporters.

Cancer Chemother. Pharmacol. 75(2) , 281-91, (2015)

Despite overall successful application to multiple myeloma patients, clinical efficacy of the proteasome inhibitor bortezomib is typically challenged by primary and secondary resistance of unknown ori...

Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.

J. Mol. Biol. 427(8) , 1765-78, (2015)

The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex performs multiple functions in transcription activation including deubiquitinating histone H2B, which is mediated by a subcomplex called the deubiquit...

Evidence for a KATP Channel in Rough Endoplasmic Reticulum (rerKATP Channel) of Rat Hepatocytes.

PLoS ONE 10 , e0125798, (2015)

We report in a previous study the presence of a large conductance K+ channel in the membrane of rough endoplasmic reticulum (RER) from rat hepatocytes incorporated into lipid bilayers. Channel activit...

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1,2,4-丁三醇

1,2,4-丁三醇用途

1,2,4-丁三醇名称

1,2,4-丁三醇物理化学性质

1,2,4-丁三醇MSDS

详细MSDS(安全技术说明书)

1,2,4-丁三醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

1,2,4-丁三醇安全信息

1,2,4-丁三醇合成路线

详细合成路线

1,2,4-丁三醇上下游产品

1,2,4-丁三醇上游产品

1,2,4-丁三醇下游产品

1,2,4-丁三醇制备

1,2,4-丁三醇海关

1,2,4-丁三醇文献

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