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山梨醇

山梨醇用途

D-Sorbitol是一种糖醇,可用作糖的替代品。

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山梨醇名称

[ CAS 号 ]:
50-70-4

[ 中文名 ]:
D-山梨醇

[ 英文名 ]:
Sorbitol

[中文别名 ]:

[英文别名 ]:

Sorbitol
D-Sorbitol
T2 T4 HEXADIENAL
EINECS 200-061-5
MFCD00004708
2,4-HEXADIEN-1-AL
trans,trans-hexa-2,4-dienal
trans,trans-2,4-Hexadienal
n-Hex-2,4-dienal
hexa-2,4-dienal

山梨醇生物活性

[ 描述 ]:

D-Sorbitol是一种糖醇,可用作糖的替代品。

[ 相关类别 ]:

研究领域 >> 其他

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. http://en.wikipedia.org/wiki/Sorbitol

[相关活性小分子]

山梨醇物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
494.9±0.0 °C at 760 mmHg

[ 熔点 ]:
98-100 °C (lit.)

[ 分子式 ]:
C₆H₁₄O₆

[ 分子量 ]:
182.172

[ 闪点 ]:
>100°C

[ 精确质量 ]:
182.079041

[ PSA ]:
121.38000

[ LogP ]:
-4.67

[ 外观性状 ]:
透明至淡黄色糖浆状液体

[ 蒸汽密度 ]:
<1 (vs air)

[ 蒸汽压 ]:
<0.1 mm Hg ( 25 °C)

[ 折射率 ]:
1.597

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
水溶性：可溶；不溶：乙醚

山梨醇MSDS

山梨醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4290000

CHEMICAL NAME :: Glucitol

CAS REGISTRY NUMBER :: 50-70-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H14-O6

MOLECULAR WEIGHT :: 182.20

WISWESSER LINE NOTATION :: Q1YQYQYQYQ1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1700 mg/kg/D

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 300 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 189,15,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80530 No. of Facilities: 16621 (estimated) No. of Industries: 86 No. of Occupations: 80 No. of Employees: 144563 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80530 No. of Facilities: 18220 (estimated) No. of Industries: 126 No. of Occupations: 121 No. of Employees: 669284 (estimated) No. of Female Employees: 461984 (estimated)

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山梨醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S8

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LZ4290000

[ 海关编码 ]:
2905440000

山梨醇合成路线

山梨醇上下游产品

山梨醇上游产品

山梨醇下游产品

山梨醇制备

1.将配制好的53%葡萄糖水溶液加入高压釜，加入葡萄糖重量0.1%的镍催化剂。经置换空气后，在约3.5MPa、150℃、pH8.2-8.4条件下加氢，终点控制残糖在0.5%以下。沉淀5min后，将所得山梨糖醇溶液通过离子交换树脂精制即得。原料消耗定额：盐酸19kg/t、液碱36kg/t、固碱6kg/t、铝镍合金粉3kg/t、口服糖518kg/t、活性炭4kg/t。

2.采用淀粉糖化所得精制葡萄糖，中压连续或间歇加氢制得。

3.将53%的葡萄糖水溶液（事先用碱液调ph＝8.2～8.4）和葡萄糖质量0.1%的镍  铝催化剂加入高压釜，排尽空气后进行反应，控制温度150℃，压力3.5MPa：

当葡萄糖含量达0.5%以下，反应即达终点。静置沉淀、过滤。滤液用强酸性苯乙烯系阳离子交换树脂001×7及强碱性系铵Ⅰ型阴离子交换树脂201×7进行精制，去除镍、铁等杂质，即得成品D-山犁醇。

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山梨醇海关

[ 海关编码 ]: 2905440000

山梨醇文献

Codon optimization of xylA gene for recombinant glucose isomerase production in Pichia pastoris and fed-batch feeding strategies to fine-tune bioreactor performance.

Bioprocess Biosyst. Eng. 38(5) , 889-903, (2015)

The objectives of this work are the optimization of the codons of xylA gene from Thermus thermophilus to enhance the production of recombinant glucose isomerase (rGI) in P. pastoris and to investigate...

Rapid detection of sugar alcohol precursors and corresponding nitrate ester explosives using direct analysis in real time mass spectrometry.

Analyst 140(8) , 2785-96, (2015)

This work highlights the rapid detection of nitrate ester explosives and their sugar alcohol precursors by direct analysis in real time mass spectrometry (DART-MS) using an off-axis geometry. Demonstr...

Vegetables' juice influences polyol pathway by multiple mechanisms in favour of reducing development of oxidative stress and resultant diabetic complications.

Pharmacogn. Mag. 10(Suppl 2) , S383-91, (2014)

Hyperglycemia induced generation of free radicals and consequent development of oxidative stress by polyol pathway is one of the crucial mechanisms stirring up development of diabetic complications. W...

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山梨醇

山梨醇用途

山梨醇名称

山梨醇生物活性

山梨醇物理化学性质

山梨醇MSDS

详细MSDS(安全技术说明书)

山梨醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

山梨醇安全信息

山梨醇合成路线

详细合成路线

山梨醇上下游产品

山梨醇上游产品

山梨醇下游产品

山梨醇制备

山梨醇海关

山梨醇文献

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