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Haloxon

Haloxon用途

Haloxon是一个抗寄生虫(线虫)化合物。

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Haloxon名称

[ CAS 号 ]:
321-55-1

[ 中文名 ]:
Haloxon

[ 英文名 ]:
Haloxon

[英文别名 ]:

Haloxon

Haloxon生物活性

[ 描述 ]:

Haloxon是一个抗寄生虫(线虫)化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 其他

[相关活性小分子]

Haloxon物理化学性质

[ 密度 ]:
1.5g/cm3

[ 沸点 ]:
504.6ºC at 760 mmHg

[ 分子式 ]:
C₁₄H₁₄Cl₃O₆P

[ 分子量 ]:
415.59000

[ 闪点 ]:
438.8ºC

[ 精确质量 ]:
413.95900

[ PSA ]:
84.78000

[ LogP ]:
4.75250

[ 折射率 ]:
1.561

[ 储存条件 ]:
2-8℃

HaloxonMSDS

详细MSDS(安全技术说明书)

Haloxon毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN5250000

CHEMICAL NAME :: Coumarin, 3-chloro-7-hydroxy-4-methyl-, bis(2-chloroethyl) phosphate

CAS REGISTRY NUMBER :: 321-55-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H14-Cl3-O6-P

MOLECULAR WEIGHT :: 415.60

WISWESSER LINE NOTATION :: T66 BOVJ DG E1 IOPO&O2GO2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 763 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 10 mg/L

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 10,143,1982 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974

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Haloxon安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H332-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
GN5250000

[ 海关编码 ]:
2932209090

Haloxon海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Haloxon文献

Effects of selected organophosphate insecticides on serum cholinesterase isoenzyme patterns in the rat.

Vet. Hum. Toxicol. 38(3) , 196-9, (1996)

The serum cholinesterase (ChE) isoenzyme in rats shows 6 bands after polyacrylamide gradient gel electrophoresis. The effects of organophosphates (fenthion, chlorpyrifos, diazinon, bromophos, propapho...

Effect of some anthelmintics on malate dehydrogenase activity and mortality in two avian nematodes Ascaridia galli and Heterakis gallinae.

Angew. Parasitol. 27(3) , 175-80, (1986)

Cambendazole and tiabendazole at 10(-4) M concentrations caused mortality in both the parasites after 10 min and 20 min, respectively. H. gallinae was killed by 10(-4) M haloxon but A. galli remained ...

Effect of cambendazole and haloxon on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae (Nematoda).

Angew. Parasitol. 31(2) , 101-5, (1990)

Cambendazole 10(-4) M significantly reduced the level of glycogen in both the parasites. Lactic acid level was found enhanced. Oxygen consumption was suppressed by 63 and 94% in A. galli and H. gallin...

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