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氟苯咪唑

氟苯咪唑用途

Flubendazole是广谱抗寄生虫化合物。

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氟苯咪唑名称

[ CAS 号 ]:
31430-15-6

[ 中文名 ]:
氟苯咪唑

[ 英文名 ]:
Flubendazole

[中文别名 ]:

[英文别名 ]:

Biovermin
Flubendazole
Flutelmium
EINECS 250-624-4
FLUVERNAL
Flubenol
fluvermal
Flumoxal
Flubenvet
MFCD00871999

氟苯咪唑生物活性

[ 描述 ]:

Flubendazole是广谱抗寄生虫化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. http://www.patentstorm.us/patents/5824336/description.html

[相关活性小分子]

氟苯咪唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
290°C

[ 分子式 ]:
C₁₆H₁₂FN₃O₃

[ 分子量 ]:
313.283

[ 精确质量 ]:
313.086273

[ PSA ]:
84.08000

[ LogP ]:
3.05

[ 外观性状 ]:
白色至淡黄色粉末

[ 折射率 ]:
1.685

[ 储存条件 ]:
-20°C

氟苯咪唑MSDS

详细MSDS(安全技术说明书)

氟苯咪唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6497500

CHEMICAL NAME :: 2-Benzimidazolecarbamic acid, 5-(p-fluorobenzoyl)-, methyl ester

CAS REGISTRY NUMBER :: 31430-15-6

LAST UPDATED :: 199410

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C16-H12-F-N3-O3

MOLECULAR WEIGHT :: 313.31

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GVR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 320 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1280 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - gastrointestinal system

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975- Volume(issue)/page/year: 340E,225,1990

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氟苯咪唑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DD6497500

[ 海关编码 ]:
2933990090

氟苯咪唑海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氟苯咪唑文献

Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs.

Expert Rev. Anti. Infect. Ther. 9(5) , 497-501, (2011)

Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions.

Int. J. Pharm. 453(2) , 343-50, (2013)

This work investigates the flocculation effect of polyethylene glycol (PEG) on typical aqueous dispersions, such as O/W emulsions and solid/liquid suspensions. Hereby, sunflower oil and flubendazole w...

Transfer of flubendazole and tylosin from feed at cross-contamination levels to various poultry matrices.

Poult. Sci. 91(9) , 2351-60, (2012)

Residues of veterinary drugs and feed additives used extensively in animal husbandry are sometimes found in edible matrices. In this study, broilers received experimental feed, containing either flube...

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