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苄丝肼

苄丝肼用途

Benserazide 是一种 PKM2 抑制剂。 Benserazide 直接结合并阻断 PKM2 酶活性,从而抑制有氧糖酵解,同时上调 OXPHOS。Benserazide可用于黑色素瘤的研究。

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苄丝肼名称

[ CAS 号 ]:
322-35-0

[ 中文名 ]:
苄丝肼

[ 英文名 ]:
2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

[中文别名 ]:

[英文别名 ]:

bensarazide
Benseraszide
Ro 4-4602
Benserazida
DL-Seryltrihydroxybenzylhydrazine
MFCD00242633
Serazide
Benserazidum

苄丝肼生物活性

[ 描述 ]:

Benserazide 是一种 PKM2 抑制剂。 Benserazide 直接结合并阻断 PKM2 酶活性,从而抑制有氧糖酵解,同时上调 OXPHOS。Benserazide可用于黑色素瘤的研究。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151.

苄丝肼物理化学性质

[ 密度 ]:
1.541 g/cm3

[ 沸点 ]:
574.2ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₅N₃O₅

[ 分子量 ]:
257.24300

[ 闪点 ]:
301ºC

[ 精确质量 ]:
257.10100

[ PSA ]:
148.07000

[ 折射率 ]:
1.678

苄丝肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT9632200

CHEMICAL NAME :: Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL-

CAS REGISTRY NUMBER :: 322-35-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H15-N3-O5

MOLECULAR WEIGHT :: 257.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23400 mg/kg/90D-C

TOXIC EFFECTS :: Behavioral - ataxia Kidney, Ureter, Bladder - other changes in urine composition Musculoskeletal - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2880 mg/kg

SEX/DURATION :: female 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982

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苄丝肼安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 海关编码 ]:
2928000090

苄丝肼海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

苄丝肼