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盐酸苄丝肼

盐酸苄丝肼用途

Benserazide盐酸盐是芳香族L-氨基酸脱羧酶(AAAD)和DOPA脱羧酶抑制剂。

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盐酸苄丝肼名称

[ CAS 号 ]:
14919-77-8

[ 中文名 ]:
盐酸苄丝肼

[ 英文名 ]:
Benserazide hydrochloride

[中文别名 ]:

[英文别名 ]:

Ro 4-4602
BENSERAZIDE HYDROCHLORIDE EP2000
EINECS 238-991-9
Benserazide HCl
BENPARIZDE
Benserazide hydrochloride
Benserazide
BENSERAZIDE HYDROCHLORIDE PERIPHERAL D
MFCD00078571
Ro 4-4602/001

盐酸苄丝肼生物活性

[ 描述 ]:

Benserazide盐酸盐是芳香族L-氨基酸脱羧酶(AAAD)和DOPA脱羧酶抑制剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Shen, H., et al., Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Tohoku J Exp Med, 2003. 199(3): p. 149-59.

[相关活性小分子]

盐酸苄丝肼物理化学性质

[ 沸点 ]:
574.2ºC at 760 mmHg

[ 熔点 ]:
146°C

[ 分子式 ]:
C₁₀H₁₆ClN₃O₅

[ 分子量 ]:
293.704

[ 精确质量 ]:
293.077850

[ PSA ]:
148.07000

[ LogP ]:
0.52790

[ 外观性状 ]:
固体，熔点146°C，水中溶解度 10 ;mg/mL

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
H2O: 10 mg/mL

盐酸苄丝肼MSDS

详细MSDS(安全技术说明书)

盐酸苄丝肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT9632300

CHEMICAL NAME :: Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, monohydrochloride, DL-

CAS REGISTRY NUMBER :: 14919-77-8

LAST UPDATED :: 199410

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H15-N3-O5.Cl-H

MOLECULAR WEIGHT :: 293.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5300 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2910 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 49,415,1985

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盐酸苄丝肼安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
VT9632300

[ 海关编码 ]:
2928000090

盐酸苄丝肼海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

盐酸苄丝肼文献

Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice

Exp. Neurol. 261 , 733-43, (2014)

γ-Aminobutyric acid A receptor (GABAAR)-mediated postsynaptic currents were recorded in brain slices from substantia nigra pars reticulate neurons. The selective adenosine A1 receptor (A1R) antagonist...

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.

Brain 137(Pt 8) , 2287-302, (2014)

Dopamine midbrain neurons within the substantia nigra are particularly prone to degeneration in Parkinson's disease. Their selective loss causes the major motor symptoms of Parkinson's disease, but th...

L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum.

J. Neurosci. Res. 92(12) , 1733-45, (2014)

L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is the most common complication of standard L-DOPA therapy for Parkinson's disease experienced by most parkinsonian patients. LID is asso...

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