6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤用途
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤名称
[ CAS 号 ]:
342-69-8
[ 中文名 ]:
6-甲硫基嘌呤核苷
[ 英文名 ]:
Inosine,6-S-methyl-6-thio-
[中文别名 ]:
[英文别名 ]:
- EINECS 206-442-2
- 6-MethylmercaptopurineRiboside
- MFCD00022826
- 6-Methylthioinosine
- METHYLTHIOINOSINE
- 6-Methylmercaptopurinribosid
- 6-methylmp-riboside
- 6-MMPR
- 6-METHYLTHIOPURINE RIBOSIDE
- 6-Methylmercaptopurine riboside
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤物理化学性质
[ 密度 ]:
1.85g/cm3
[ 沸点 ]:
636.3ºC at 760mmHg
[ 熔点 ]:
166°C
[ 分子式 ]:
C11H14N4O4S
[ 分子量 ]:
298.32
[ 闪点 ]:
338.6ºC
[ 精确质量 ]:
298.07400
[ PSA ]:
138.82000
[ 外观性状 ]:
白色粉末
[ 折射率 ]:
1.822
[ 储存条件 ]:
−20°C
[ 稳定性 ]:
Incompatible with strong oxidizing agents.
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤MSDS
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UO8985000
- CHEMICAL NAME :
- 9H-Purine, 6-(methylthio)-9-beta-D-ribofuranosyl-
- CAS REGISTRY NUMBER :
- 342-69-8
- BEILSTEIN REFERENCE NO. :
- 0042871
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C11-H14-N4-O4-S
- MOLECULAR WEIGHT :
- 298.35
- WISWESSER LINE NOTATION :
- T56 BN DN FN HNJ IS1 D- BT5OTJ CQ DQ E1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 137 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 44 mg/kg/7W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 780 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - adrenal cortex tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 65 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 3 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,1587,1983
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 安全声明 (欧洲) ]:
S22-S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
UO8985000
[ 海关编码 ]:
29349990
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤合成路线
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤上下游产品
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤上游产品
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤下游产品
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤文献
Ther. Drug Monit. 33 , 200-208, (2011)
There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) h...
Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa.Biochemistry 51(45) , 9094-103, (2012)
Pseudomonas aeruginosa possesses an unusual pathway for 5'-methylthioadenosine (MTA) metabolism involving deamination to 5'-methylthioinosine (MTI) followed by N-ribosyl phosphorolysis to hypoxanthine...
A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis.Scand. J. Gastroenterol. 40(10) , 1205-13, (2005)
6-thioguanine (6-TG) has emerged as a promising therapeutic alternative in patients with Crohn's disease intolerant or resistant to azathioprine (AZA) and/or 6-mercaptopurine (6-MP). The aim of the pr...
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