腺苷
腺苷用途
1.抗心律失常药,可使阵发性室上性心动过速转为窦性心律。用于和房室有关的室上心律失常。
2.治疗心绞痛、心肌梗塞、冠脉功能不全、动脉硬化、原发性高血压、脑血管障碍、中风后遗症、进行性肌肉萎缩等。
3.生化研究。
腺苷名称
[ CAS 号 ]:
58-61-7
[ 中文名 ]:
腺苷
[ 英文名 ]:
Adenosine
[中文别名 ]:
[英文别名 ]:
- Adenosin
- 9β-D-ribofuranosyl-9H-Purin-6-amine
- Adesine
- 1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-Ribofuranose
- 6-Amino-9-b-D-ribofuranosyl-9H-purine
- Adenocor
- Sandesin
- 9-β-δ-Ribofuranosidoadenine
- (-)-adenosine
- 9-β-δ-Ribofuranosyl-9H-purin-6-amine
腺苷生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Human Endogenous Metabolite
[参考文献]
[相关活性小分子]
腺苷物理化学性质
[ 密度 ]:
2.1±0.1 g/cm3
[ 沸点 ]:
676.3±65.0 °C at 760 mmHg
[ 熔点 ]:
234-236ºC
[ 分子式 ]:
C10H13N5O4
[ 分子量 ]:
267.241
[ 闪点 ]:
362.8±34.3 °C
[ 精确质量 ]:
267.096741
[ PSA ]:
139.54000
[ LogP ]:
-1.02
[ 外观性状 ]:
白色结晶粉末
[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C
[ 折射率 ]:
1.907
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.
腺苷MSDS
腺苷毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AU7175000
- CHEMICAL NAME :
- Adenosine
- CAS REGISTRY NUMBER :
- 58-61-7
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C10-H13-N5-O4
- MOLECULAR WEIGHT :
- 267.28
- WISWESSER LINE NOTATION :
- T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 240 ug/kg
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 143 ug/kg/I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - headache
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 50 ug/kg/1M-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - bronchiolar constriction
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 360 ug/kg/1H-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Cardiac - change in rate
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 257 ug/kg
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 171 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - pulse rate
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 257 ug/kg/1D-I
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >20 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 60 mmol/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,24,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3937 No. of Facilities: 77 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 556 (estimated) No. of Female Employees: 387 (estimated)
腺苷安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
Xn
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
AU7175000
[ 海关编码 ]:
2934999090
腺苷合成路线
腺苷上下游产品
腺苷上游产品
腺苷下游产品
腺苷海关
[ 海关编码 ]: 2934999090
[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
腺苷文献
Thromb. Haemost. 112(1) , 142-50, (2014)
ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influen...
The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus.FEBS Lett. 589(6) , 750-5, (2015)
The cyclic AMP phosphodiesterases type 4 (PDE4s) are expressed in a cell specific manner, with intracellular targeting directed by unique N-terminal anchor domains. All long form PDE4s are phosphoryla...
Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.J. Neurosci. 34(35) , 11769-80, (2014)
Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hip...
相关化工产品/化学物质:
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公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:腺苷
公司名:南通润丰石油化工有限公司
区域:南通市崇川区
价格:
¥需询单/1kg
¥需询单/1ton
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产品详情:腺苷
公司名:云南西力生物技术股份有限公司
区域:昆明市盘龙区
价格:
¥需询单/5mg
联系人:郑雪平
产品详情:腺苷
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥78.0/5g
¥258.0/25g
¥108.0/20mg
联系人:刘佳
产品详情:腺嘌呤核苷
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
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相关化合物
【腺苷】化源网提供腺苷CAS号58-61-7,腺苷MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询腺苷上化源网,专业又轻松。>>电脑版:腺苷
标题:腺苷_MSDS_用途_密度_腺苷CAS号【58-61-7】_化源网 地址:https://m.chemsrc.com/mip/cas/58-61-7_85738.html