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L-硫代脯氨酸

L-硫代脯氨酸用途

(R) -噻唑烷-4-羧酸是脯氨酸衍生物[1]。

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L-硫代脯氨酸名称

[ CAS 号 ]:
34592-47-7

[ 中文名 ]:
L-硫代脯氨酸

[ 英文名 ]:
L-Thioproline

[中文别名 ]:

[英文别名 ]:

H-THZ-OH
L-Thiazolidine-4-car
(R)-4-Thiazolidinecarboxylic acid
EINECS 252-106-3
L-THC
THIAPROLINE
(4R)-4-Thiazolidinecarboxylic acid
(4R)-thiazolidine-4-carboxylic acid
1,3-Thiazolidine-2-carboxylic acid
Thiazolidinecarboxylic acid (VAN)

L-硫代脯氨酸生物活性

[ 描述 ]:

(R) -噻唑烷-4-羧酸是脯氨酸衍生物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。

[参考文献]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

L-硫代脯氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
350.3±37.0 °C at 760 mmHg

[ 熔点 ]:
190-200 °C (dec.)(lit.)

[ 分子式 ]:
C₄H₇NO₂S

[ 分子量 ]:
133.169

[ 闪点 ]:
165.7±26.5 °C

[ 精确质量 ]:
133.019745

[ PSA ]:
74.63000

[ LogP ]:
-0.39

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.566

[ 储存条件 ]:
2~8℃，干燥

[ 水溶解性 ]:
28.5 g/L (20 ºC)

L-硫代脯氨酸MSDS

L-硫代脯氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ5425500

CHEMICAL NAME :: 4-Thiazolidinecarboxylic acid, L-

CAS REGISTRY NUMBER :: 34592-47-7

LAST UPDATED :: 199610

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H7-N-O2-S

MOLECULAR WEIGHT :: 133.18

WISWESSER LINE NOTATION :: T5M CSTJ EVQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2547728

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00644

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L-硫代脯氨酸安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
XJ5425500

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29341000

L-硫代脯氨酸合成路线

L-硫代脯氨酸上下游产品

L-硫代脯氨酸上游产品

L-硫代脯氨酸下游产品

L-硫代脯氨酸海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-硫代脯氨酸文献

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Bioorg. Med. Chem. 19 , 6409-18, (2011)

The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...

Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors.

Biochimie 94(2) , 533-40, (2012)

Herein we describe the design, synthesis and biological activities of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors. The target compounds 2a-2j were d...

Successful computer guided planned synthesis of (4R)-thiazolidine carboxylic acid and its 2-substituted analogues as urease inhibitors.

Mol. Divers. 10(2) , 223-31, (2006)

By using internal combinatorial library we were able to identify (4R)-thiazolidines carboxylic acid and its 2-substituted analogs as active inhibitors of urease. Molecular modeling and virtual screeni...

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