替卡西林

替卡西林用途

替卡西林是一种半合成、广谱、羧青霉素抗菌剂,对革兰氏阳性球菌(包括链球菌和葡萄球菌)具有活性。替卡西林对大多数革兰氏阴性菌也有效,包括铜绿假单胞菌。替卡西林可用于下呼吸道感染、皮肤和皮肤结构感染、尿路感染和腹腔内感染研究[1][2][3]。

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替卡西林名称

[ CAS 号 ]:
34787-01-4

[ 中文名 ]:
替卡西林添加剂

[ 英文名 ]:
Ticarcillin

[中文别名 ]:

替卡西林

[英文别名 ]:

Temocillin Disodium
EINECS 252-213-5
Ticarcillin
a-Carboxy-3-thienylmethylpenicillin
TRIARCILLIN
MFCD00864998
Ticcarcillin acid

替卡西林生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

替卡西林处理(10mg/L；18h)显示出抗菌活性[1]。细胞活力测定[2]细胞系：铜绿假单胞菌浓度：10 mg/L孵育时间：18小时结果：替卡西林对菌株的MIC在6.3-12.5 mg/L之间。

[体内研究]

替卡西林(皮下注射；50、100、200 mg/kg；一次)治疗显示出剂量依赖性抗菌作用[2]。替卡西林(皮下注射；50、100、200 mg/kg；一次)治疗显示出良好的药代动力学评估[2]。动物模型：瑞士型雄性小鼠注射铜绿假单胞菌[2]剂量：50、100、200 mg/kg给药：皮下注射；50、100、200mg/kg；一次结果：随着剂量的增加,效应显著增加(0.001

[参考文献]

[1]. Cecile Formosa, et al. Nanoscale effects of antibiotics on P. aeruginosa. Nanomedicine. 2012 Jan;8(1):12-6.

[2]. G B van der Voet, et al. Comparison of the antibacterial activity of azlocillin and ticarcillin in vitro and in irradiated neutropenic mice. J Antimicrob Chemother. 1985 Nov;16(5):605-13.

[3]. Oriel Spierer, et al. Comparative activity of antimicrobials against Pseudomonas aeruginosa, Achromobacter xylosoxidans and Stenotrophomonas maltophilia keratitis isolates. Br J Ophthalmol. 2018 May;102(5):708-712.

替卡西林物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
768.3±60.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₆N₂O₆S₂

[ 分子量 ]:
384.427

[ 闪点 ]:
418.4±32.9 °C

[ 精确质量 ]:
384.044983

[ PSA ]:
177.55000

[ LogP ]:
0.69

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.694

[ 储存条件 ]:
2-8°C

替卡西林安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
22-36/37-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

替卡西林文献

Methyl gallate from Galla rhois successfully controls clinical isolates of Salmonella infection in both in vitro and in vivo systems.

PLoS ONE 9(7) , e102697, (2014)

Galla rhois is a commonly used traditional medicine for the treatment of pathogenic bacteria in Korea as well as in other parts of Asia. Methyl gallate (MG), a major component of Galla Rhois, exhibits...

Genetic characterization of oropharyngeal trichomonad isolates from wild birds indicates that genotype is associated with host species, diet and presence of pathognomonic lesions.

Avian Pathol. 43(6) , 535-46, (2014)

Oropharyngeal trichomonad isolates of wild birds from Spain were studied. A total of 1688 samples (1214 of predator birds and 474 of prey species) from wildlife recovery centres and scientific bird-ri...

Characterization of Acinetobacter baumannii clinical isolates carrying bla(OXA-23) carbapenemase and 16S rRNA methylase armA genes in Yemen.

Microb. Drug Resist. 20(6) , 604-9, (2014)

The aim of this study was to investigate the molecular support of resistance to carbapenems, aminoglycosides, and fluoroquinolones in Acinetobacter baumannii clinical isolates collected from Yemen hos...

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