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杀稻瘟菌素 S

杀稻瘟菌素 S用途

Blasticidin S hydrochloride 是从 Streptomyces griseochromogenes 中分离的核苷抗生素。Blasticidin S 抑制原核细胞和真核细胞中蛋白质合成。

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杀稻瘟菌素 S名称

[ CAS 号 ]:
3513-03-9

[ 中文名 ]:
灭瘟素S盐酸盐

[ 英文名 ]:
blasticidin s hydrochloride

[英文别名 ]:

MFCD02091640
Blasticidine S hydrochloride
BlasticidinS,monohydrochloride (8CI)
Blasticidin S hydrochloride

杀稻瘟菌素 S生物活性

[ 描述 ]:

Blasticidin S hydrochloride 是从 Streptomyces griseochromogenes 中分离的核苷抗生素。Blasticidin S 抑制原核细胞和真核细胞中蛋白质合成。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

杀稻瘟素S(BlaS)是一种广谱抗生素,可抑制原核生物,真菌,植物和哺乳动物细胞的细胞生长[1]。

[参考文献]

[1]. Kitamura K, et al. Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398.

杀稻瘟菌素 S物理化学性质

[ 沸点 ]:
772.1ºC at 760 mmHg

[ 分子式 ]:
C₁₇H₂₇ClN₈O₅

[ 分子量 ]:
458.90

[ 闪点 ]:
420.8ºC

[ 精确质量 ]:
458.17900

[ PSA ]:
215.67000

[ LogP ]:
1.05570

[ 外观性状 ]:
固体

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Soluble in water. Insoluble in organic solvents.

杀稻瘟菌素 SMSDS

详细MSDS(安全技术说明书)

杀稻瘟菌素 S安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

杀稻瘟菌素 S文献

A rice fungicide blasticidin S efficiently binds Cu(II) ions and prevents DNA from metal-induced damage.

J. Inorg. Biochem. 127 , 73-8, (2013)

Blasticidin S is a representative of the aminoacylnucleoside class of antibiotics and it possesses fungicidal properties against the virulent fungus which causes a serious rice blast disease in Asia. ...

Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome.

Proc. Natl. Acad. Sci. U. S. A. 110(30) , 12283-8, (2013)

The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and...

Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.

Proc. Natl. Acad. Sci. U. S. A. 103 , 13485-13490, (2006)

Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and rel...

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