格列布唑
格列布唑名称
[ CAS 号 ]:
3567-08-6
[ 中文名 ]:
格列布唑
[ 英文名 ]:
Benzenesulfonamide,4-methoxy-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-
[英文别名 ]:
- Isobuzole
- Wy-2340
- Isopamin
- SADA
格列布唑物理化学性质
[ 密度 ]:
1.37g/cm3
[ 沸点 ]:
517.5ºC at 760mmHg
[ 分子式 ]:
C13H17N3O3S2
[ 分子量 ]:
327.42200
[ 闪点 ]:
266.8ºC
[ 精确质量 ]:
327.07100
[ PSA ]:
117.80000
[ LogP ]:
3.69980
[ 折射率 ]:
1.589
格列布唑毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DB2780000
- CHEMICAL NAME :
- Benzenesulfonamide, N-(5-isobutyl-1,3,4-thiadiazol-2-yl)-p-methoxy-
- CAS REGISTRY NUMBER :
- 3567-08-6
- BEILSTEIN REFERENCE NO. :
- 0295174
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C13-H17-N3-O3-S2
- MOLECULAR WEIGHT :
- 327.45
- WISWESSER LINE NOTATION :
- T5NN DSJ CMSWR DO1& E1Y1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 534 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 468 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Endocrine - hypoglycemia Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,631,1962
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 214 gm/kg/52W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,13,1966 *** REVIEWS *** TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970
格列布唑安全信息
[ 海关编码 ]:
2935009090
格列布唑合成路线
格列布唑上下游产品
格列布唑上游产品
格列布唑下游产品
格列布唑海关
[ 海关编码 ]: 2935009090
[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
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