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铬变素FB

铬变素FB用途

Carmoisine (Azorubine) 是一种偶氮染料,可用作食品添加剂。

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铬变素FB名称

[ CAS 号 ]:
3567-69-9

[ 中文名 ]:
4-羟基-3-(4-磺酸-1-萘偶氮)-1-萘磺酸二钠盐

[ 英文名 ]:
Carmoisine

[中文别名 ]:

[英文别名 ]:

Carmoisine B
EINECS 222-657-4
foodred5
red#14
Mordant Blue 79
Chromotrope FB
carmoisin
AZORUBIN
Azorubine
Brilliant Crimson Red

铬变素FB生物活性

[ 描述 ]:

Carmoisine (Azorubine) 是一种偶氮染料,可用作食品添加剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

胭脂红可促进中性粒细胞体外合成白三烯B4(LTB4)和F2异丙醇。胭脂红增加血液中性粒细胞在所有测试浓度下F2异丙醇的形成[2]。

[体内研究]

胭脂红(49.3-493 mg/kg；口服；42天；雄性Wistar大鼠)治疗显著增加低浓度和高浓度MAPK8的表达,NFκB和GADD45α的表达没有改变[1]。动物模型：雄性Wistar大鼠(120-300g)[1]剂量：49.3mg/kg,493mg/kg给药：口服；42天结果：根据MAPK8的表达导致细胞凋亡。

[参考文献]

[1]. B Raposa, et al. Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFκB, GADD45α, and MAPK8 genes. Physiol Int. 2016 Sep;103(3):334-343.

[2]. Latasha Leo, et al. Occurrence of azo food dyes and their effects on cellular inflammatory responses. Nutrition. 2018 Feb;46:36-40.

铬变素FB物理化学性质

[ 熔点 ]:
>300ºC

[ 分子式 ]:
C₂₀H₁₂N₂Na₂O₇S₂

[ 分子量 ]:
502.428

[ 闪点 ]:
>225℃

[ 精确质量 ]:
501.988129

[ PSA ]:
176.11000

[ LogP ]:
6.08380

[ 外观性状 ]:
红色粉末

[ 储存条件 ]:
室温

铬变素FBMSDS

铬变素FB毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK1925000

CHEMICAL NAME :: 1-Naphthalenesulfonic acid, 4-hydroxy-3,4'-azodi-, disodium salt

CAS REGISTRY NUMBER :: 3567-69-9

LAST UPDATED :: 199703

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C20-H12-N2-O7-S2.2Na

MOLECULAR WEIGHT :: 502.44

WISWESSER LINE NOTATION :: L66J BSWQ ENUN- CL66J BQ ESWQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 74 gm/kg/90D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 300 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,133,1989 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,83,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,83,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1431 No. of Facilities: 92 (estimated) No. of Industries: 3 No. of Occupations: 14 No. of Employees: 1771 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1431 No. of Facilities: 2819 (estimated) No. of Industries: 39 No. of Occupations: 49 No. of Employees: 38995 (estimated) No. of Female Employees: 8194 (estimated)

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铬变素FB安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
QK1925000

铬变素FB合成路线

铬变素FB上下游产品

铬变素FB上游产品

铬变素FB下游产品

铬变素FB制备

1,4-氨基萘磺酸钠重氮化，与NW酸(1-萘酚-4-磺酸)偶合，盐析而得。1.重氮化将200kg1,4氨基萘磺酸钠溶解在1000L水中。加15%盐酸492kg。析出乳白色结晶。冷至10℃从液面下加入30%亚硝酸钠溶液(折100%57.6kg)，加料温度控制在25℃以下，使淀粉磺化钾试纸呈微蓝色，保持1.5h。得1,4-氨基萘磺酸重氮盐溶液。2.偶合桶内加水1250ml、纯碱192kg和NW酸89kg，搅拌使全部溶解。冷至15℃，2h内徐徐加入上述重氮盐溶液，加料温度不超过25℃。加毕，测定pH=8.5搅拌30min。终点为重氮盐消失，NW酸应微过量。到达终点后，再搅拌3h。升温至65-70℃，按体积23%加盐盐析。过滤。滤饼干燥，粉碎，标准化得酸性红B染料成品620kg。原料消耗(kg/t)NW酸(100%) 323 碳酸钠(98%) 2681,4-氨基萘磺酸钠(100%) 340 盐酸(31%) 369亚硝酸钠(98%) 98 精盐 597

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铬变素FB文献

Determination of vanadium in groundwater samples with an improved kinetic spectrophotometric method.

Environ. Technol. 35(9-12) , 1165-74, (2014)

A kinetic catalytic method has been developed for the determination of vanadium based on its catalytic effect on the redox reaction of azorubin S and bromate in the presence of a sulphuric and nitric ...

Toxic effects of some synthetic food colorants and/or flavor additives on male rats.

Toxicol. Ind. Health 29(2) , 224-32, (2013)

The objective of the present work was to evaluate the broadest toxic effect of some synthetic additives of colorants and/or flavors on different body organs and metabolic aspects in rats. A number of ...

Pattern of intake of food additives associated with hyperactivity in Irish children and teenagers.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 27(4) , 447-56, (2010)

A double-blind randomized intervention study has previously shown that a significant relationship exists between the consumption of various mixes of seven target additives by children and the onset of...

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铬变素FB

铬变素FB用途

铬变素FB名称

铬变素FB生物活性

铬变素FB物理化学性质

铬变素FBMSDS

详细MSDS(安全技术说明书)

铬变素FB毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

铬变素FB安全信息

铬变素FB合成路线

详细合成路线

铬变素FB上下游产品

铬变素FB上游产品

铬变素FB下游产品

铬变素FB制备

铬变素FB文献

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