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3-脱氧鸟苷

3-脱氧鸟苷用途

3'-脱氧鸟苷(鸟苷,3'-脱氧-)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

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3-脱氧鸟苷名称

[ CAS 号 ]:
3608-58-0

[ 中文名 ]:
3’-脱氧鸟苷

[ 英文名 ]:
3'-Deoxyguanosine

[中文别名 ]:

3-脱氧鸟苷

[英文别名 ]:

3'-Deoxy-D-guanosine
MFCD00079149
3'-deoxyriboguanosine
3'-Deoxyguanosine
3'-deoxyguanosine monohydrate
3'-deoxy-guanosine
3'-DG
Guanosine, 3'-deoxy-

3-脱氧鸟苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

3-脱氧鸟苷物理化学性质

[ 密度 ]:
2.1±0.1 g/cm3

[ 沸点 ]:
725.5±70.0 °C at 760 mmHg

[ 熔点 ]:
<300℃ (water )

[ 分子式 ]:
C₁₀H₁₃N₅O₄

[ 分子量 ]:
267.24

[ 闪点 ]:
392.6±35.7 °C

[ 精确质量 ]:
267.096741

[ PSA ]:
140.01000

[ LogP ]:
-0.72

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.907

[ 储存条件 ]:
-20℃，干燥，避光

3-脱氧鸟苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

3-脱氧鸟苷合成路线

详细合成路线

3-脱氧鸟苷上下游产品

3-脱氧鸟苷上游产品

3-脱氧鸟苷下游产品

3-脱氧鸟苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-脱氧鸟苷文献

Rat brain guanosine binding site. Biological studies and pseudo-receptor construction.

Bioorg. Med. Chem. 11 , 5417-5425, (2003)

Rat brain guanosine binding sites were studied by (i). a pharmacological approach to confirm the hypothesis of the existence of specific G-coupled receptors for guanosine (1) and, for the first time, ...

Structure of human PNP complexed with ligands.

Acta Crystallogr. D Biol. Crystallogr. 61 , 856-862, (2005)

Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine-salvage pathway, which allows cells to utilize preformed bases and nucleosides in order to synthesize nucleotides. PNP is specific f...

Effects of polyadenylation inhibition on meiosis progression in relation to the polyadenylation status of cyclins A2 and B1 during in vitro maturation of bovine oocytes.

Mol. Reprod. Dev. 71 , 107-114, (2005)

The control of protein synthesis during maturation in oocytes is mainly exerted through cytoplasmic polyadenylation of stored mRNAs. We first analyzed the polyadenylation status of cyclins A2 and B1 d...

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