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5-溴-2,4-二氯嘧啶

5-溴-2,4-二氯嘧啶名称

[ CAS 号 ]:
36082-50-5

[ 中文名 ]:
5-溴-2,4-二氯嘧啶

[ 英文名 ]:
5-Bromo-2,4-dichloropyrimidine

[中文别名 ]:

[英文别名 ]:

5-bromo-2,4-dichloropyrimdine
Pyrimidine, 5-bromo-2,4-dichloro-
5-Brom-2,4-dichlor-pyrimidin
5-Bromo-2,4-dichloropyrimidine
MFCD00127818
2,4,4-TRIMETHYLCYCLOPENTANONE
5-Bromo-2,4-dichloro-pyrimidine
2,4-Dichloro-5-bromo pyrimidine
5-Bromo-2,4-dichloror-pyrimidine

5-溴-2,4-二氯嘧啶物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
287.5±20.0 °C at 760 mmHg

[ 熔点 ]:
29-30 °C(lit.)

[ 分子式 ]:
C₄HBrCl₂N₂

[ 分子量 ]:
227.874

[ 闪点 ]:
127.7±21.8 °C

[ 精确质量 ]:
225.870010

[ PSA ]:
25.78000

[ LogP ]:
2.06

[ 外观性状 ]:
淡黄色固体或液体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.605

[ 储存条件 ]:
Keep Cold

[ 水溶解性 ]:
可溶于：甲醇

5-溴-2,4-二氯嘧啶MSDS

详细MSDS(安全技术说明书)

5-溴-2,4-二氯嘧啶安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H314-H317

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P2 (EN 143) respirator cartridges;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/24/25;R34

[ 安全声明 (欧洲) ]:
S26-S27-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3263 8/PG 2

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2933599090

5-溴-2,4-二氯嘧啶合成路线

详细合成路线

5-溴-2,4-二氯嘧啶上下游产品

5-溴-2,4-二氯嘧啶上游产品

5-溴-2,4-二氯嘧啶下游产品

5-溴-2,4-二氯嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-溴-2,4-二氯嘧啶文献

Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.

J. Med. Chem. 56(23) , 9683-92, (2013)

Abnormal activation or overexpression of Mer receptor tyrosine kinase has been implicated in survival signaling and chemoresistance in many human cancers. Consequently, Mer is a promising novel cancer...

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Bioorg. Med. Chem. Lett. 17(22) , 6206-11, (2007)

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.

Synthesis , 861, (2006)

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