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5-溴脲嘧啶

5-溴脲嘧啶用途

5-溴脲醛是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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5-溴脲嘧啶名称

[ CAS 号 ]:
51-20-7

[ 中文名 ]:
5-溴尿嘧啶

[ 英文名 ]:
5-Bromouracil

[中文别名 ]:

[英文别名 ]:

Uracil,5-bromo
2,4(1H,3H)-Pyrimidinedione, 5-bromo-
Bromouracil
5-Bromo-2,4(1H,3H)-pyrimidinedione
5-bromo-uraci
5-bromopyrimidine-2,4-diol
5-bromo-2,4-dioxopyrimidine
5-Bromouracil
5-BrUra
5-Br-uracil

5-溴脲嘧啶生物活性

[ 描述 ]:

5-溴脲醛是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

5个-溴尿嘧啶通过诱导 A.型样脱氧核糖核酸破坏核小体定位。

5-溴脲嘧啶物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
384ºC

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₄H₃BrN₂O₂

[ 分子量 ]:
190.98

[ 精确质量 ]:
189.937775

[ PSA ]:
65.72000

[ LogP ]:
-0.35

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.590

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
SOLUBLE IN COLD WATER

5-溴脲嘧啶MSDS

5-溴脲嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ9060000

CHEMICAL NAME :: Uracil, 5-bromo-

CAS REGISTRY NUMBER :: 51-20-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C4-H3-Br-N2-O2

MOLECULAR WEIGHT :: 191.00

WISWESSER LINE NOTATION :: T6MVMVJ EE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5 gm/kg/2W-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Insect - grasshopper

DOSE/DURATION :: 10 mg

REFERENCE :: IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921- Volume(issue)/page/year: 38,305,1963

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5-溴脲嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R46

[ 安全声明 (欧洲) ]:
S36/37-S53-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YQ9060000

[ 海关编码 ]:
29335995

5-溴脲嘧啶合成路线

5-溴脲嘧啶上下游产品

5-溴脲嘧啶上游产品

5-溴脲嘧啶下游产品

5-溴脲嘧啶制备

将L-丙氨酸悬浮于二氧六环溶液中，与叔丁氧羰基叠氮进行酰化反应得粗产品，再经重结晶精制而得。

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5-溴脲嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-溴脲嘧啶文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.

Nat. Commun. 6 , 6715, (2015)

The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery...

Bench scale synthesis of p-hydroxybenzoic acid using whole-cell nitrilase of Gordonia terrae mutant E9.

Bioprocess Biosyst. Eng. 38 , 1267-79, (2015)

Mutants of Gordonia terrae were generated using chemical mutagens for better activity, stability and higher substrate/product tolerance of its nitrilase enzyme. Mutant E9 showed two-time increase in a...

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5-溴脲嘧啶

5-溴脲嘧啶用途

5-溴脲嘧啶名称

5-溴脲嘧啶生物活性

5-溴脲嘧啶物理化学性质

5-溴脲嘧啶MSDS

详细MSDS(安全技术说明书)

5-溴脲嘧啶毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

5-溴脲嘧啶安全信息

5-溴脲嘧啶合成路线

详细合成路线

5-溴脲嘧啶上下游产品

5-溴脲嘧啶上游产品

5-溴脲嘧啶下游产品

5-溴脲嘧啶制备

5-溴脲嘧啶海关

5-溴脲嘧啶文献

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