2,4-二氟苯胺

2,4-二氟苯胺用途

【用途一】
用作合成医药、农药、染料的中间体
【用途二】
2,4-二氟苯胺是有机合成的中间体。医药上用于二氟苯水杨酸和多氟啶酸的合成。氟苯水杨酸是羧酸类非甾抗炎药，国际非专有药名（INN）为Diflunisal。这个水杨酸的新衍生物结构中不含有阿司匹林的乙酰基而含有二氟苯基，所以抗血小板的副作用小，且胃肠道反应轻微，作用时间可维持8-12h，可能是水杨酸类药物中最有发展前途的品种。也是农药的重要中间体。

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2,4-二氟苯胺名称

[ CAS 号 ]:
367-25-9

[ 中文名 ]:
2,4-二氟苯胺

[ 英文名 ]:
2,4-Difluoroaniline

[中文别名 ]:

2.4-二氟苯胺

[英文别名 ]:

2,4-difluorophenylamine
2,4-DIFLOUROANILINE
Benzenamine, 2,4-difluoro-
Difluoroaniline
4-Difluoroaniline
2,4-Difluoranilin
2,4-difluoro-anilin
2,4-difluorobenzenamine
2,4-difluorobenzeneamine
Aniline,2,4-difluoro

2,4-二氟苯胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
168.4±20.0 °C at 760 mmHg

[ 熔点 ]:
−7.5 °C(lit.)

[ 分子式 ]:
C₆H₅F₂N

[ 分子量 ]:
129.107

[ 闪点 ]:
62.8±0.0 °C

[ 精确质量 ]:
129.039001

[ PSA ]:
26.02000

[ LogP ]:
1.52

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
1.6±0.3 mmHg at 25°C

[ 折射率 ]:
1.521

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.

[ 水溶解性 ]:
1-5 g/100 mL at 20.55 ºC

2,4-二氟苯胺MSDS

详细MSDS(安全技术说明书)

2,4-二氟苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX3680000

CHEMICAL NAME :: Aniline, 2,4-difluoro-

CAS REGISTRY NUMBER :: 367-25-9

BEILSTEIN REFERENCE NO. :: 2802556

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H5-F2-N

MOLECULAR WEIGHT :: 129.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988

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2,4-二氟苯胺安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H311-H331

[ 警示性声明 ]:
P261-P280-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S28-S36/37/39-S26

[ 危险品运输编码 ]:
UN 2941 6.1/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
BX3680000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2921420090

2,4-二氟苯胺合成路线

详细合成路线

2,4-二氟苯胺上下游产品

2,4-二氟苯胺上游产品

2,4-二氟苯胺下游产品

2,4-二氟苯胺制备

1.2,4-二氟硝基苯还原法将铁粉和氯化铵水溶液加入还原釜中，加热升温至回流后，滴加2,4-二氟硝基苯，加完回流2h，反应完毕，用水蒸气蒸馏，馏出液分离后，用氯化钙干燥，即可得合格产品，收率87%。

2.由1,2,4-三氯苯经硝化、氟代及还原脱氯而得；或由间苯二胺经重氮化、置换、硝化、还原而得。

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2,4-二氟苯胺海关

[ 海关编码 ]: 2921420090

[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2,4-二氟苯胺文献

2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analyses.

Int. Arch. Occup. Environ. Health 54(3) , 223-32, (1984)

Two possible methods for monitoring exposure to 2,4-difluoroaniline and 4-fluoroaniline have been investigated: measurement of methaemoglobin content in blood and measurement of urinary metabolites. E...

Subacute toxicity assessment of water disinfection byproducts on zebrafish.

Pathol. Oncol. Res. 18(3) , 579-84, (2012)

Disinfection of raw water is essential to the production of drinking water. However, by-products of disinfection may exert toxic effects. The potential toxic effects of two of these compounds, 4-ethyl...

High resolution NMR study of T1 magnetic relaxation dispersion. III. Influence of spin 1/2 hetero-nuclei on spin relaxation and polarization transfer among strongly coupled protons.

J. Chem. Phys. 137(9) , 094503, (2012)

Effects of spin-spin interactions on the nuclear magnetic relaxation dispersion (NMRD) of protons were studied in a situation where spin ½ hetero-nuclei are present in the molecule. As in earlier work...

更多文献

2,4-二氟苯胺

2,4-二氟苯胺用途

2,4-二氟苯胺名称

2,4-二氟苯胺物理化学性质

2,4-二氟苯胺MSDS

详细MSDS(安全技术说明书)

2,4-二氟苯胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2,4-二氟苯胺安全信息

2,4-二氟苯胺合成路线

详细合成路线

2,4-二氟苯胺上下游产品

2,4-二氟苯胺上游产品

2,4-二氟苯胺下游产品

2,4-二氟苯胺制备

2,4-二氟苯胺海关

2,4-二氟苯胺文献

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