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井冈霉素

井冈霉素用途

用途一：为内吸性杀菌剂。主要防治水稻纹枯病，持效期15～20d，耐雨水冲刷。在水稻纹枯病盛发初期，每隔10d（或半月）喷雾1次，用量5%水剂15～22.5mL/100m2，共喷2～3次。井冈霉素还可防治小粒菌核病，稻曲病，玉米大斑病，玉米穗腐病，玉米、豆类立枯病、白绢病，人参、棉花、蔬菜立枯病。
用途二：主治水稻、三麦纹枯病，玉米大斑病，蔬菜立枯病、白粉病，人参立枯病。
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井冈霉素名称

[ CAS 号 ]:
37248-47-8

[ 中文名 ]:
井冈霉素

[ 英文名 ]:
Validamycin

[中文别名 ]:

[英文别名 ]:

井冈霉素生物活性

[ 描述 ]:

Validamycin A 是一种氨基糖苷类农用抗生素。Validamycin A 能抑制黄曲霉的生长, 其 MIC 值为 1 μg/mL。Validamycin A 是一种可逆的酪氨酸酶抑制剂,其 Ki 值为 5.893 mM。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 抗感染 >> 真菌
信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶

[ 靶点 ]

Ki: 5.893 mM (tyrosinase)[2]


[体外研究]

validamycina(0.5-1μg/mL；18h)抑制黄曲霉生长和分生孢子萌发延迟[1]。缬霉素A对人支气管上皮细胞无细胞毒性[1]。缬霉素A直接与酪氨酸酶活性部位的几个残基结合,包括HIS85、HIS244、GLU256、HIS259和ASN260[1]。细胞增殖试验[1]细胞株：黄曲霉ATCC204304浓度：0.5μg/mL,1μg/mL孵育时间：18h结果：抑制黄曲霉生长。

[参考文献]

[1]. Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415.

[2]. Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23.

井冈霉素物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
813.7±65.0 °C at 760 mmHg

[ 熔点 ]:
130-135ºC

[ 分子式 ]:
C20H35NO13

[ 分子量 ]:
497.491

[ 闪点 ]:
445.9±34.3 °C

[ 精确质量 ]:
497.210846

[ PSA ]:
253.02000

[ LogP ]:
-5.43

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±6.6 mmHg at 25°C

[ 折射率 ]:
1.689

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

井冈霉素MSDS

详细MSDS(安全技术说明书)

井冈霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM7540000
CHEMICAL NAME :
D-chiro-Inositol, 1,5,6-trideoxy-3-O-beta-D-glucopyranosyl-5-(hydroxyme thyl)-1-((4,5,6- trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino) -, (1S-(1-alpha,4-alpha,5-beta, 6-alpha))-
CAS REGISTRY NUMBER :
37248-47-8
LAST UPDATED :
199606
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C20-H35-N-O13
MOLECULAR WEIGHT :
497.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (15),28,1973
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S29,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (40),32,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 1,229,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (47),17,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>13 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (15),28,1973
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井冈霉素安全信息

[ 危害码 (欧洲) ]:
T+

井冈霉素合成路线

详细合成路线

井冈霉素上下游产品

井冈霉素上游产品

井冈霉素下游产品

井冈霉素制备

由吸水链霉素井冈变种发酵提取制成。工艺流程：砂土管—母斜面—茄子瓶—种子罐—发酵罐—放罐
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相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：井冈霉素A

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥848.0/250mg

联系人：刘佳

产品详情：井冈霉素A

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥1731.0/1g ￥1146.0/500mg ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Validamycin A

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥642.9/250mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：井冈霉素A

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥655.0/250mg ￥1707.16/1g ￥1133.86/500mg

联系人：夏言

产品详情：[Perfemiker]井冈霉素,分析对照品

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