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[HYP3]BRADYKININ

[HYP3]BRADYKININ用途

[Hyp3]-Bradykinin 是一种天然存在的肽激素,是一种缓激肽受体 (bradykinin receptor) 激动剂。[Hyp3]-Bradykinin 与 B2-缓激肽受体相互作用并刺激人成纤维细胞中肌醇磷酸的产生。

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[HYP3]BRADYKININ名称

[ CAS 号 ]:
37642-65-2

[ 中文名 ]:
[HYP3]BRADYKININ

[ 英文名 ]:
[Hyp<sup>3</sup>]Bradykinin

[英文别名 ]:

[Hyp(3)]-bradykinin
[HYP3]-BRADYKININ (HUMAN) 2ACOH 3H2O
bradykinin,hydroxy-Pro(3)
[HYP3]-BRADYKININ
BRADYKININ [HYP3]
[HYP3]-BRADYKININ (HUMAN)
Bradykinin[Hyp3]

[HYP3]BRADYKININ生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 缓激肽受体

[体外研究]

[Hyp3]-缓激肽在与牛子宫肌层结合的能力以及在离体大鼠子宫上的效力方面与天然缓激肽一样活跃[1]。

[参考文献]

[1]. R Dengler, et al. [Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin interact with B2-bradykinin receptors and stimulate inositol phosphate production in cultured human fibroblasts. FEBS Lett. 1990 Mar 12;262(1):111-4.

[HYP3]BRADYKININ物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₅₀H₇₃N₁₅O₁₂

[ 分子量 ]:
1076.208

[ 精确质量 ]:
1075.556274

[ PSA ]:
434.01000

[ LogP ]:
-1.09

[ 折射率 ]:
1.700

[ 储存条件 ]:
-20°C

[HYP3]BRADYKININ安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[HYP3]BRADYKININ文献

Bradykinin receptors and their antagonists.

Eur. J. Pharmacol. 348 , 1-10, (1998)

Bradykinin and related kinins act on two receptor types, named B1 and B2. Initially identified in classical bioassays, these receptors have been cloned and characterized in binding assays performed on...

Bradykinin receptor types and B2 subtypes.

Life Sci. 55 , 735-749, (1994)

Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characteriza...

Isolation and identification of hydroxyproline analogues of bradykinin in human urine.

FEBS Lett. 232 , 252, (1988)

Hydroxyproline (Hyp) analogues of bradykinin and lysyl-bradykinin, in which the third residue of bradykinin, proline, is replaced by hydroxyproline, were isolated from human urine. Their amino acid se...

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