< 生产厂家价格 >

6-Hydroxykynurenic acid

6-Hydroxykynurenic acid用途

6-Hydroxykynurenic acid (6-HKA) 是犬尿酸 (KYNA) 衍生物,能从银杏叶中分离得到。6-Hydroxykynurenic acid 是 NMDAR 的低亲和力拮抗剂 (IC50: 59 μM)。

点击显示

6-Hydroxykynurenic acid名称

[ CAS 号 ]:
3778-29-8

[ 英文名 ]:
6-Hydroxykynurenic acid

[英文别名 ]:

6-Hydroxykynurenic acid
4,6-dihydroxy-2-carboxyquinoline
6-Hydroxykynureninsaeure
4,6-dihydroxy-quinoline-2-carboxylic acid
Quinaldic acid,4,6-dihydroxy
6-Hydroxykynurensaeure
6-Hydroxykynurenate
4,6-Dihydroxyquinaldic acid
4,6-Dihydroxy-chinolin-2-carbonsaeure

6-Hydroxykynurenic acid生物活性

[ 描述 ]:

6-Hydroxykynurenic acid (6-HKA) 是犬尿酸 (KYNA) 衍生物,能从银杏叶中分离得到。6-Hydroxykynurenic acid 是 NMDAR 的低亲和力拮抗剂 (IC50: 59 μM)。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[ 靶点 ]

IC50: 59 μM (NMDAR)[1]

[参考文献]

[1]. Weber M, et al. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. J Neurochem. 2001 May;77(4):1108-15.

6-Hydroxykynurenic acid物理化学性质

[ 密度 ]:
1.569g/cm3

[ 沸点 ]:
455.6ºC at 760mmHg

[ 分子式 ]:
C₁₀H₇NO₄

[ 分子量 ]:
205.16700

[ 闪点 ]:
229.4ºC

[ 精确质量 ]:
205.03800

[ PSA ]:
90.39000

[ LogP ]:
0.93190

[ 折射率 ]:
1.681

6-Hydroxykynurenic acid安全信息

[ 海关编码 ]:
2933499090

6-Hydroxykynurenic acid上下游产品

6-Hydroxykynurenic acid上游产品

6-Hydroxykynurenic acid下游产品

6-Hydroxykynurenic acid海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%