N-丁基-N-(4-羟丁基)亚硝胺
N-丁基-N-(4-羟丁基)亚硝胺名称
[ CAS 号 ]:
3817-11-6
[ 中文名 ]:
N-丁基-N-(4-羟丁基)亚硝胺
[ 英文名 ]:
N-Butyl-N-(4-hydroxybutyl)nitrosamine
[中文别名 ]:
[英文别名 ]:
- 4-Hydroxybutylbutylnitrosamine
- N-Butyl-N-butan-4-ol-nitrosamine
- N-Nitrosobutylbutanolamine
- Butyl-butanol-nitrosamine
- N-N-Butyl-N-Butan-4-Ol-Nitrosamine
- Butylhydroxybutylnitrosamine
- N-Butyl-N-(4-hydroxybutyl)nitrosaMine
N-丁基-N-(4-羟丁基)亚硝胺物理化学性质
[ 密度 ]:
1.02g/cm3
[ 沸点 ]:
320.2ºC at 760mmHg
[ 分子式 ]:
C8H18N2O2
[ 分子量 ]:
174.24100
[ 闪点 ]:
147.5ºC
[ 精确质量 ]:
174.13700
[ PSA ]:
52.90000
[ LogP ]:
1.54240
[ 外观性状 ]:
红色液体
[ 折射率 ]:
1.474
[ 储存条件 ]:
0-10°C;存放于惰性气体之中;避免光,空气,加热
N-丁基-N-(4-羟丁基)亚硝胺MSDS
N-丁基-N-(4-羟丁基)亚硝胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EL1225000
- CHEMICAL NAME :
- 1-Butanol, 4-(butylnitrosoamino)-
- CAS REGISTRY NUMBER :
- 3817-11-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 35
- MOLECULAR FORMULA :
- C8-H18-N2-O2
- MOLECULAR WEIGHT :
- 174.28
- WISWESSER LINE NOTATION :
- Q4N4&NO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Vascular - other changes Blood - hemorrhage
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 560 mg/kg/8W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Tumorigenic - increased incidence of tumors in susceptible strains
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg/10W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - normocytic anemia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 100 mg/kg female 14 day(s) after conception
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 22500 mg/kg/75W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - colon tumors Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg/8W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1348 mg/kg/8W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 280 mg/kg/4W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg/8W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2800 mg/kg/8W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1820 mg/kg/26W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12 gm/kg/43W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1200 mg/kg/10W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1638 mg/kg/20W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2100 mg/kg/6W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- Morphological transformation
- TYPE OF TEST :
- Unscheduled DNA synthesis
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 900 mg/L/27H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,277,1979 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 17,51,1978 TOXICOLOGY REVIEW GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 17,161,1975 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266, Phildelphia, PA 19103) V.1- 1978- Volume(issue)/page/year: 3,109,1981 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983
N-丁基-N-(4-羟丁基)亚硝胺安全信息
[ 危害码 (欧洲) ]:
T: Toxic;
[ 风险声明 (欧洲) ]:
45-22
[ 安全声明 (欧洲) ]:
S53
[ RTECS号 ]:
EL1225000
[ 海关编码 ]:
2928000090
N-丁基-N-(4-羟丁基)亚硝胺合成路线
N-丁基-N-(4-羟丁基)亚硝胺上下游产品
N-丁基-N-(4-羟丁基)亚硝胺上游产品
N-丁基-N-(4-羟丁基)亚硝胺下游产品
N-丁基-N-(4-羟丁基)亚硝胺海关
[ 海关编码 ]: 2928000090
[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
推荐生产厂家/供应商：
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥231.9/1g
￥3049.9/25g
￥774.9/5g
￥需询单/1g
联系人：阿拉丁
产品详情：N-丁基-N-(4-羟丁基)亚硝胺
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥288.0/1g
￥988.0/5g
￥3225.0/25g
联系人：夏言
产品详情：[Perfemiker]N-丁基-N-(4-羟丁基)亚硝胺,>90.0%(GC)
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