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17α-羟孕烯醇酮

17α-羟孕烯醇酮用途

17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮 (DHEA) 的一种激素原。

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17α-羟孕烯醇酮名称

[ CAS 号 ]:
387-79-1

[ 中文名 ]:
17Alpha-羟基妊娠烯醇酮

[ 英文名 ]:
17a-Hydroxypregnenolone

[中文别名 ]:

[英文别名 ]:

MFCD00021129
Pregnan-2-one, 3,17-dihydroxy-
Hydroxypregnenolone
EINECS 206-862-6
HYDROXYPREGNENOLONE,17A
17a-Hydroxypregnolone
17alpha-Hydroxy
5-Pregnen-3.β.,17.α.-diol-20-one
17-OH PREG
3,17-Dihydroxypregnan-2-one

17α-羟孕烯醇酮生物活性

[ 描述 ]:

17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮 (DHEA) 的一种激素原。

[ 相关类别 ]:

研究领域 >> 内分泌

[ 靶点 ]

Human Endogenous Metabolite

17α-羟孕烯醇酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
468.1±40.0 °C at 760 mmHg

[ 熔点 ]:
273℃

[ 分子式 ]:
C₂₁H₃₂O₃

[ 分子量 ]:
334.493

[ 闪点 ]:
251.0±23.8 °C

[ 精确质量 ]:
334.250793

[ PSA ]:
57.53000

[ LogP ]:
3.46

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.540

[ 储存条件 ]:
?20°C

17α-羟孕烯醇酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5548000

CHEMICAL NAME :: Pregn-5-en-20-one, 3-beta,17-dihydroxy-

CAS REGISTRY NUMBER :: 387-79-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H32-O3

MOLECULAR WEIGHT :: 332.53

WISWESSER LINE NOTATION :: L E5 B666 LUTJ A1 E1 FV1 FQ OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 99600 ug/kg

SEX/DURATION :: male 48 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 5,45,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 96 mg/kg

SEX/DURATION :: male 48 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,484,1973

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17α-羟孕烯醇酮安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol

[ WGK德国 ]:
3

[ RTECS号 ]:
TU5548000

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17α-羟孕烯醇酮文献

Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.

J. Biol. Chem. 288(23) , 17008-18, (2013)

The membrane heme protein cytochrome b5 (b5) can enhance, inhibit, or have no effect on cytochrome P450 (P450) catalysis, depending on the specific P450, substrate, and reaction conditions, but the st...

Serum concentrations of adrenal steroids and their precursors as a measure of maturity of adrenocortical function in very premature newborns.

Horm. Res. Paediatr. 74(5) , 358-64, (2010)

Relative adrenocortical insufficiency is often seen in sick premature newborns. As the human fetal adrenal cortex does not express the 3β-hydroxysteroid dehydrogenase (3β-HSD) enzyme before about 23 w...

Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical carcinoma.

Endocr. J. 58(7) , 527-34, (2011)

Adrenocortical carcinoma (ACC) is a very rare malignant tumor with poor prognosis. To gain insight into the pathogenic significance of ACC, we studied clinicopathological features and gene expression ...

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