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羟孕酮

羟孕酮用途

【用途一】
用作甾体激素药中间体
【用途二】
氢化可的松、甲地孕酮、己酸孕酮的中间体。

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羟孕酮名称

[ CAS 号 ]:
68-96-2

[ 中文名 ]:
17Alpha-羟基黄体酮

[ 英文名 ]:
17α-hydroxyprogesterone

[中文别名 ]:

[英文别名 ]:

17α-Hydroxypregn-4-ene-3,20-dione
17-Hydroxypregn-4-en-3,20-dione
MFCD00003659
hydroxyprogesteronum [INN_la]
17-Hydroxypregn-4-ene-3,20-dione
4-Pregnen-17a-ol-3,20-dione
4-Pregnen-17α-ol-3,20-dione
17alpha-hydroxyprogesterone
Pregn-4-ene-3,20-dione, 17-hydroxy-
17α-Hydroxyprogesterone

羟孕酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
482.9±45.0 °C at 760 mmHg

[ 熔点 ]:
276°C

[ 分子式 ]:
C₂₁H₃₀O₃

[ 分子量 ]:
330.461

[ 闪点 ]:
260.0±25.2 °C

[ 精确质量 ]:
330.219482

[ PSA ]:
54.37000

[ LogP ]:
2.89

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.560

[ 储存条件 ]:
-20?C Freezer

[ 水溶解性 ]:
可溶于：氯仿

羟孕酮MSDS

羟孕酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5060000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17-hydroxy-

CAS REGISTRY NUMBER :: 68-96-2

BEILSTEIN REFERENCE NO. :: 2062088

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H30-O3

MOLECULAR WEIGHT :: 330.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 65 mg/kg

SEX/DURATION :: female 8-32 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 26,151,1960

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,18,1956

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羟孕酮安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
61

[ 安全声明 (欧洲) ]:
S53-S22-S36/37/39-S45

[ 危险品运输编码 ]:
2811.0

[ WGK德国 ]:
3

[ RTECS号 ]:
TU5060000

羟孕酮合成路线

羟孕酮上下游产品

羟孕酮上游产品

羟孕酮下游产品

羟孕酮制备

【方法一】
可用薯蓣皂素经开环、乙酰化、氧化、水解、环氧化、氧化、加成、催化氢化等步反应制得。

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羟孕酮文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

更多文献

羟孕酮

羟孕酮用途

羟孕酮名称

羟孕酮物理化学性质

羟孕酮MSDS

详细MSDS(安全技术说明书)

羟孕酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

羟孕酮安全信息

羟孕酮合成路线

详细合成路线

羟孕酮上下游产品

羟孕酮上游产品

羟孕酮下游产品

羟孕酮制备

羟孕酮文献

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