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4-溴苯甲胺

4-溴苯甲胺用途

有机合成中间体。

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4-溴苯甲胺名称

[ CAS 号 ]:
3959-07-7

[ 中文名 ]:
对溴苄胺

[ 英文名 ]:
4-Bromobenzylamine

[中文别名 ]:

[英文别名 ]:

p-Bromobenzylamine
4-Bromobenzylamine
1-(4-Bromophenyl)methanamine
Benzenemethanamine, 4-bromo-
EINECS 223-559-4
MFCD00047931
(4-bromophenyl)methanamine

4-溴苯甲胺物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
248.9±15.0 °C at 760 mmHg

[ 熔点 ]:
25 °C(lit.)

[ 分子式 ]:
C₇H₈BrN

[ 分子量 ]:
186.049

[ 闪点 ]:
104.3±20.4 °C

[ 精确质量 ]:
184.984009

[ PSA ]:
26.02000

[ LogP ]:
1.86

[ 外观性状 ]:
无色至黄色透明液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.590

[ 储存条件 ]:
室温，密封

4-溴苯甲胺MSDS

4-溴苯甲胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R21/22;R34

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3259 8/PG 2

[ WGK德国 ]:
3

4-溴苯甲胺合成路线

4-溴苯甲胺上下游产品

4-溴苯甲胺上游产品

4-溴苯甲胺下游产品

4-溴苯甲胺制备

烧瓶中加入300g(5mol)乙酰胺及250g(1mol)对溴苄溴;加热熔化后开动搅拌,将下层的对溴苄溴搅起来使混合均匀。继续加热至170℃,放热反应开始(停止加热),调整反应温度180~190℃反应1h,析出大量乙酰胺溴氢酸盐;放热反应缓和后,于1h左右分两次再加入250g(1mol)对溴苄溴,再于180~190℃条件下反1.5h;冷却至70~80℃将反应物倾入于1L冷水中,充分搅拌以洗去溴氢酸乙酰胺;继续冷却N-乙酰对溴苄胺凝固,倾去水层;再用热水洗一次,滤出,得490g(湿)产物。①水解400mL水中加入400g(4mol)浓硫酸,加入上面的粗乙酰化物,在电热上回流3h,放冷至80℃将上层水溶液移入于2L烧杯中(下层少许油状物弃去)放置过夜,次日滤出硫酸盐结晶,用100mL冷水冲洗,所得硫酸盐近于理论量(母液蒸除去乙酸后调正硫酸浓度酸可重新用于水解)。②中和250g苛性钠溶于750mL水中,配成1.0kg25%NaOH溶液,维持60~70℃,将上面的硫酸盐撒开加入,保温下搅拌至少0.5h使中和完全。冷后分出下面淡黄色油层,得340~360g。用苛性钠干燥后减压馏,收122~128℃(2.0kPa)馏分,得215g(58%)冰点>18产物。

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4-溴苯甲胺文献

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.

Proc. Natl. Acad. Sci. U. S. A. 111(23) , 8428-33, (2014)

Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms have causal relationships with a range of ...

Common metal of copper(0) as an efficient catalyst for preparation of nitriles and imines by controlling additives.

Chem. Commun. (Camb.) 50(42) , 5637-40, (2014)

A novel, efficient, convenient and environmentally friendly approach for the synthesis of nitriles and imines from primary amines has been developed. Using commercially available red copper as the cat...

Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity.

Bioorg. Med. Chem. 15(11) , 3896-911, (2007)

We have designed and synthesized two novel series of MCH-R1 antagonists based on a substituted biphenylmethyl urea core. SAR was explored, suggesting that optimal binding with the receptor was achieve...

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