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L-赖氨酸一水物

L-赖氨酸一水物用途

蛋白研究用，培养基添加剂。

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L-赖氨酸一水物名称

[ CAS 号 ]:
39665-12-8

[ 中文名 ]:
L-赖氨酸一水物

[ 英文名 ]:
L(+)-Lysine monohydrate

[中文别名 ]:

[英文别名 ]:

L-Lysine monohydrate
L-Lysine hydrate
lysine,hydrate
L-LYS H2O
LYS,MONOHYDRATE
EINECS 200-294-2
H-Lys-OH H2O
MFCD00151035

L-赖氨酸一水物生物活性

[ 描述 ]:

水合赖氨酸是一种必需氨基酸。水合赖氨酸可用于研究血管钙化(VC)和急性胰腺炎[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

研究领域 >> 炎症/免疫

[ 靶点 ]

Microbial Metabolite

Human Endogenous Metabolite

[体外研究]

水合赖氨酸(VSMCs)抑制血浆iPTH并升高血浆丙氨酸、脯氨酸、血浆精氨酸和高精氨酸,从而抑制VSMCs的凋亡和矿物质沉淀[1]。

[体内研究]

水合赖氨酸(40μg/kg；p.o.)改善腺嘌呤大鼠的动脉钙化,并保护股骨免受腺嘌呤鼠骨质疏松变化的影响[1]。赖氨酸水合物(10和400 mg/kg；i.g.和p.o.；雄性小鼠)抑制胰腺组织损伤[2]。动物模型：雄性小鼠[2]剂量：10和400 mg/kg给药：腹腔注射和口服；15天结果：抑制炎症细胞因子IL-6的释放,增强抗氧化活性。

[参考文献]

[1]. Shimomura A, et, al. Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65.

[2]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193.

L-赖氨酸一水物物理化学性质

[ 沸点 ]:
400ºC at 760 mmHg

[ 熔点 ]:
212-214 °C

[ 分子式 ]:
C₆H₁₆N₂O₃

[ 分子量 ]:
164.20300

[ 闪点 ]:
195.7ºC

[ 精确质量 ]:
164.11600

[ PSA ]:
98.57000

[ LogP ]:
0.86360

[ 外观性状 ]:
白色至略黄色结晶粉末

[ 储存条件 ]:
室温，密封，干燥

[ 水溶解性 ]:
>1500 g/L (20 ºC)

L-赖氨酸一水物MSDS

详细MSDS(安全技术说明书)

L-赖氨酸一水物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
OL5540000

[ 海关编码 ]:
2922411000

L-赖氨酸一水物海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

L-赖氨酸一水物文献

Direct cellular delivery of human proteasomes to delay tau aggregation.

Nat. Commun. 5 , 5633, (2014)

The 26S proteasome is the primary machinery that degrades ubiquitin (Ub)-conjugated proteins, including many proteotoxic proteins implicated in neurodegeneraton. It has been suggested that the elevati...

A new antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties.

J. Biol. Chem. 255 , 976, (1980)

L-Lysine alpha-oxidase from Trichoderma viride Y244-2 has been purified to homogeneity. The enzyme shows absorption maxima at 277, 388, and 466 nm and a shoulder around 490 nm and contains 2 mol of FA...

Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling.

PLoS Pathog. 11(12) , e1005346, (2015)

Epstein-Barr virus (EBV) is etiologically linked to infectious mononucleosis and several human cancers. EBV encodes a conserved protein kinase BGLF4 that plays a key role in the viral life cycle. To p...

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