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丝裂霉素A

丝裂霉素A用途

Mitomycin A 是细菌的代谢物。Mitomycin A 可降低迁移抑制因子 (MIF) 的产生,可用于癌症研究。

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丝裂霉素A名称

[ CAS 号 ]:
4055-39-4

[ 中文名 ]:
丝裂霉素A

[ 英文名 ]:
Mitomycin A

[英文别名 ]:

mitomycin-A
Mitomycin A

丝裂霉素A生物活性

[ 描述 ]:

Mitomycin A 是细菌的代谢物。Mitomycin A 可降低迁移抑制因子 (MIF) 的产生,可用于癌症研究。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. van der Nat JM, et al. Suppression of migration inhibition factor (MIF) production by mitomycins in vitro. Immunobiology. 1986 Aug;172(1-2):120-7.

丝裂霉素A物理化学性质

[ 密度 ]:
1.5g/cm3

[ 沸点 ]:
587.4ºC at 760 mmHg

[ 熔点 ]:
159-161ºC (dec)

[ 分子式 ]:
C₁₆H₁₉N₃O₆

[ 分子量 ]:
349.34

[ 闪点 ]:
309.1ºC

[ 精确质量 ]:
349.12700

[ PSA ]:
130.10000

[ LogP ]:
0.00350

[ 外观性状 ]:
红色-紫罗兰色晶体

[ 蒸汽压 ]:
8.83E-14mmHg at 25°C

[ 折射率 ]:
1.638

[ 储存条件 ]:
室温

丝裂霉素A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CN1050000

CAS REGISTRY NUMBER :: 4055-39-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H19-N3-O6

MOLECULAR WEIGHT :: 349.38

WISWESSER LINE NOTATION :: T D3 B556 BN EM JV MVTTT&J GO1 H1OVZ KO1 L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 3 ug/L

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,767,1977

丝裂霉素A

丝裂霉素A用途

丝裂霉素A名称

丝裂霉素A生物活性

丝裂霉素A物理化学性质

丝裂霉素A毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

丝裂霉素A合成路线

详细合成路线

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