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泊非霉素

泊非霉素用途

Porfiromycin是一种生物还原性烷基化剂,相对于其他需氧化合物,它优先杀死缺氧肿瘤细胞。
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泊非霉素名称

[ CAS 号 ]:
801-52-5

[ 中文名 ]:
泊非霉素

[ 英文名 ]:
Porfiromycin

[英文别名 ]:

泊非霉素生物活性

[ 描述 ]:

Porfiromycin是一种生物还原性烷基化剂,相对于其他需氧化合物,它优先杀死缺氧肿瘤细胞。

[ 相关类别 ]:

研究领域 >> 癌症
信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂

[参考文献]

[1]. Keyes SR, Rockwell S, Sartorelli AC. Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res. 1985;45(8):3642-3645.

泊非霉素物理化学性质

[ 密度 ]:
1.52g/cm3

[ 沸点 ]:
560.9ºC at 760 mmHg

[ 分子式 ]:
C16H20N4O5

[ 分子量 ]:
348.35400

[ 闪点 ]:
293ºC

[ 精确质量 ]:
348.14300

[ PSA ]:
127.96000

[ 折射率 ]:
1.672

泊非霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CN0525000
CAS REGISTRY NUMBER :
801-52-5
LAST UPDATED :
199709
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C16-H20-N4-O5
MOLECULAR WEIGHT :
348.40
WISWESSER LINE NOTATION :
T D3 B556 BN EN JV MVTTT&J E1 GO1 H1OVZ KZ L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - thrombocytopenia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
68 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
88660 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
44 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
53500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Blood - granulocytopenia
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>10 mg/kg
TOXIC EFFECTS :
Blood - granulocytopenia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
84 mg/kg/28D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
2 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,3939,1986
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推荐生产厂家/供应商：

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥2708.0/1mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：Porfiromycin-d3

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