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2',3'-二脱氧-3'-氟尿苷

2',3'-二脱氧-3'-氟尿苷用途

2′,3′-二脱氧-3′-氟尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

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2',3'-二脱氧-3'-氟尿苷名称

[ CAS 号 ]:
41107-56-6

[ 中文名 ]:
3′-氟-2′,3′-二脱氧尿苷

[ 英文名 ]:
2′,3′-Dideoxy-3′-fluorouridine

[中文别名 ]:

[英文别名 ]:

Fddurd
URIDINE,2',3'-DIDEOXY-3'-FLUORO
EINECS 415-360-8
3'-FLUORO-2',3'-DIDEOXYURIDINE
MFCD00192015
2'3'-dideoxy-3'-fluorouridine

2',3'-二脱氧-3'-氟尿苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

2',3'-二脱氧-3'-氟尿苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 熔点 ]:
184-188ºC(lit.)

[ 分子式 ]:
C₉H₁₁FN₂O₄

[ 分子量 ]:
230.19

[ 精确质量 ]:
230.070282

[ PSA ]:
84.32000

[ LogP ]:
-1.11

[ 外观性状 ]:
灰白色固体

[ 折射率 ]:
1.577

[ 储存条件 ]:
-20°C

2',3'-二脱氧-3'-氟尿苷MSDS

详细MSDS(安全技术说明书)

2',3'-二脱氧-3'-氟尿苷安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H341

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R68

[ 安全声明 (欧洲) ]:
22-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ 海关编码 ]:
29349990

2',3'-二脱氧-3'-氟尿苷文献

Synthesis and in vitro antiviral activities of 3'-fluoro (or chloro) and 2',3'-difluoro 2',3'-dideoxynucleoside analogs against hepatitis B and C viruses.

Bioorg. Med. Chem. 18(21) , 7542-7, (2010)

Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) lead to serious liver diseases worldwide. Co-infection with HBV and HCV is very common and is associated with increased risk...

Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.

J. Biol. Chem. 264 , 6127, (1989)

3'-Azido-2',3'-dideoxythymidine (AZT) and 2',3'-didehydro-2',3'-dideoxythymidine (D4T) are potent and selective inhibitors of human immunodeficiency virus replication in MT-4 and ATH8 cells. They are ...

Perspectives for the chemotherapy of AIDS.

Chemioterapia 7(6) , 357-64, (1988)

Several steps in the replicative cycle of human immunodeficiency virus (HIV) could be envisaged as targets for anti-AIDS drugs. The anionic compound PMEA [9-(2-phosphonyl-methoxyethyl)adenine], the 2'...

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