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2',3'-二脱氧尿苷

2',3'-二脱氧尿苷用途

2',3'-二脱氧尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

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2',3'-二脱氧尿苷名称

[ CAS 号 ]:
5983-09-5

[ 中文名 ]:
2’,3’-二脱氧尿苷

[ 英文名 ]:
2',3'-Dideoxyuridine

[中文别名 ]:

[英文别名 ]:

MFCD00013359

2',3'-二脱氧尿苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

2',3'-二脱氧尿苷物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 熔点 ]:
127-129 °C(lit.)

[ 分子式 ]:
C₉H₁₂N₂O₄

[ 分子量 ]:
212.20

[ 精确质量 ]:
226.095352

[ PSA ]:
84.32000

[ LogP ]:
-0.76

[ 折射率 ]:
1.552

[ 储存条件 ]:
2~8°C

2',3'-二脱氧尿苷MSDS

2',3'-二脱氧尿苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
C

[ 风险声明 (欧洲) ]:
34-36/37

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

2',3'-二脱氧尿苷合成路线

2',3'-二脱氧尿苷上下游产品

2',3'-二脱氧尿苷上游产品

2',3'-二脱氧尿苷下游产品

2',3'-二脱氧尿苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2',3'-二脱氧尿苷文献

Abacavir and metabolite pharmacokinetics in HIV-1-infected children and adolescents.

J. Acquir. Immune Defic. Syndr. 51(1) , 54-9, (2009)

Abacavir (ABC) oral clearance, adjusted for body size, is approximately 2 times higher for children than adults with a corresponding difference in dose regimens. However, there are limited data availa...

Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate.

Mol. Pharmacol. 37(2) , 157-63, (1990)

2',3'-Dideoxyuridine (ddUrd) exhibits poor if any anti-human immunodeficiency virus (HIV) activity in ATH8 and MT-4 cells. This is in agreement with the failure of ddUrd to be efficiently anabolized i...

Glycosyl-oxycarbonylaminosulfonyl-2',3'-dideoxynucleoside derivatives as lipophilic nucleotide mimics. Synthesis and anti-HIV activity.

Bioorg. Med. Chem. 1(4) , 279-84, (1993)

Several lipophilic-2',3'-dideoxynucleotide analogues have been synthesized and tested against Human Immunodeficiency Virus (HIV). Glycosyl-oxycarbonylaminosulfonyl-analogues of 3'-deoxythymidine and 2...

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