4,7,10-三氧-1,13-十三烷二胺

4,7,10-三氧-1,13-十三烷二胺用途

PROTAC Linker 24 是一种 PROTAC 连接桥,属于 alkyl/ether 类。PROTAC Linker 24 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过连接桥连接的不同配体; 一种是 E3 泛素连接酶配体,另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

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4,7,10-三氧-1,13-十三烷二胺名称

[ CAS 号 ]:
4246-51-9

[ 中文名 ]:
4,7,10-三氧-1,13-十三烷二胺

[ 英文名 ]:
4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

[中文别名 ]:

[英文别名 ]:

4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
3,3'-[OXYBIS(ETHANE-2,1-DIYLOXY)]DIPROPAN-1-AMINE
Diethylene Glycol Bis(3-aMinopropyl) Ether
EINECS 224-207-2
MFCD00059850
3,3'-[Oxybis(2,1-ethanediyloxy)]di(1-propanamine)
Bis[2-(3-aminopropoxy)ethyl] Ether

4,7,10-三氧-1,13-十三烷二胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl/ether

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

4,7,10-三氧-1,13-十三烷二胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
310.6±0.0 °C at 760 mmHg

[ 熔点 ]:
-32 °C

[ 分子式 ]:
C₁₀H₂₄N₂O₃

[ 分子量 ]:
220.309

[ 闪点 ]:
148.0±17.4 °C

[ 精确质量 ]:
220.178696

[ PSA ]:
79.73000

[ LogP ]:
-1.51

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.464

[ 储存条件 ]:
室温，密封

4,7,10-三氧-1,13-十三烷二胺MSDS

4,7,10-三氧-1,13-十三烷二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ID6475000

CHEMICAL NAME :: Diethylene glycol, di(3-aminopropyl) ether

CAS REGISTRY NUMBER :: 4246-51-9

BEILSTEIN REFERENCE NO. :: 1760709

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H24-N2-O3

MOLECULAR WEIGHT :: 220.36

WISWESSER LINE NOTATION :: Z3O2O2O3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4290 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1067 No. of Facilities: 307 (estimated) No. of Industries: 10 No. of Occupations: 10 No. of Employees: 13486 (estimated) No. of Female Employees: 3955 (estimated)

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4,7,10-三氧-1,13-十三烷二胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
ID6475000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2922199090

4,7,10-三氧-1,13-十三烷二胺合成路线

4,7,10-三氧-1,13-十三烷二胺上下游产品

4,7,10-三氧-1,13-十三烷二胺上游产品

4,7,10-三氧-1,13-十三烷二胺下游产品

4,7,10-三氧-1,13-十三烷二胺海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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