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3,3'-二碘甲腺原氨酸

3,3'-二碘甲腺原氨酸用途

3,3'-Diiodo-L-thyronine (3,3'-T2) 是一种甲状腺激素的内源性代谢产物 (endogenous metabolite)。3,3'-Diiodo-L-thyronine 显着增强 COX 活性。

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3,3'-二碘甲腺原氨酸名称

[ CAS 号 ]:
4604-41-5

[ 中文名 ]:
3,3'-二碘甲腺原氨酸

[ 英文名 ]:
3,3'-diiodo-L-thyronine

[中文别名 ]:

[英文别名 ]:

3,3’-Diiodo-L-thyronine
O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
3,3'-Diiodo-L-thyronine
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3-iodo-
EINECS 225-005-7

3,3'-二碘甲腺原氨酸生物活性

[ 描述 ]:

3,3'-Diiodo-L-thyronine (3,3'-T2) 是一种甲状腺激素的内源性代谢产物 (endogenous metabolite)。3,3'-Diiodo-L-thyronine 显着增强 COX 活性。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> COX

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

COX

[体外研究]

3,3'-二碘-L-甲状腺素(3,3'-T2；1μM；30min)显著增强COX活性[2]。1μM的3,3'-二碘-L-甲状腺素的影响最大[2]。3,3'-二碘-L-甲状腺素通过进一步降解T3和rT3产生[3]。

[参考文献]

[1]. Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88.

[2]. Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99(1):89-94.

[3]. Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32(6):e4185.

3,3'-二碘甲腺原氨酸物理化学性质

[ 密度 ]:
2.1±0.1 g/cm3

[ 沸点 ]:
520.7±50.0 °C at 760 mmHg

[ 熔点 ]:
178-180ºC

[ 分子式 ]:
C₁₅H₁₃I₂NO₄

[ 分子量 ]:
525.077

[ 闪点 ]:
268.7±30.1 °C

[ 精确质量 ]:
524.893372

[ PSA ]:
92.78000

[ LogP ]:
4.55

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.726

[ 储存条件 ]:
Amber Vial, -20°C Freezer, Under Inert Atmosphere

3,3'-二碘甲腺原氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

3,3'-二碘甲腺原氨酸文献

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