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Hellebrigenin

Hellebrigenin用途

Hellebrigenin,属于心脏活性类固醇的丁二烯内酯之一,从中药中分离出来。Hellebrigenin 诱导 DNA 损伤和细胞周期 G2/M 阻滞。 Hellebrigenin 触发线粒体介导的细胞凋亡。

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Hellebrigenin名称

[ CAS 号 ]:
465-90-7

[ 中文名 ]:
蟾蜍它里定

[ 英文名 ]:
Bufotalidin

[英文别名 ]:

EINECS 207-368-3
Bufotalidin
Hellebrigenin
Gellebrigenin

Hellebrigenin生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Deng LJ, et al. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chem Biol Interact. 2014 Aug 5;219:184-94.

Hellebrigenin物理化学性质

[ 密度 ]:
1.419g/cm3

[ 沸点 ]:
626.3ºC at 760 mmHg

[ 熔点 ]:
175 °C

[ 分子式 ]:
C₂₄H₃₂O₆

[ 分子量 ]:
416.50700

[ 闪点 ]:
215ºC

[ 精确质量 ]:
416.22000

[ PSA ]:
107.97000

[ LogP ]:
2.53580

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.675

[ 储存条件 ]:
2-8°C，密封，干燥

Hellebrigenin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI3175800

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-beta,5,14-trihydroxy-19-oxo-

CAS REGISTRY NUMBER :: 465-90-7

BEILSTEIN REFERENCE NO. :: 0056259

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C24-H32-O6

MOLECULAR WEIGHT :: 416.56

WISWESSER LINE NOTATION :: L E5 B666TJ AVH E1 IQ MQ OQ F- ET6OVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 77 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1345 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 252,314,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 514 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb, Yugoslavia) V.1-41, 1951-1991. Volume(issue)/page/year: 24,179,1974 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,191,1963