5,8-二羟基-1,4-萘醌

5,8-二羟基-1,4-萘醌用途

Naphthazarin (DHNQ) 是天然存在的化合物,通过多种细胞机制有效,包括氧化应激,线粒体凋亡诱导因子 (AIF) 活化,微管解聚,干扰溶酶体功能和 p53 依赖性 p21 活化。Naphthazarin 触发细胞凋亡 (apoptosis) 并具有抗肿瘤作用。

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5,8-二羟基-1,4-萘醌名称

[ CAS 号 ]:
475-38-7

[ 中文名 ]:
萘茜

[ 英文名 ]:
Naphthazarin

[中文别名 ]:

[英文别名 ]:

5,8-Dihydroxy-1,4-naphthalenedione
EINECS 207-495-4
MFCD00001685
5,8-Dihydroxy-1,4-naphthoquinone
5,8-dihydroxynaphthalene-1,4-dione
Naphthazarin

5,8-二羟基-1,4-萘醌生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 神经疾病

[参考文献]

[1]. Seon Young Choi, et al. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. J Neurosci Res. 2012 Sep;90(9):1842-9.

[2]. Omar Aljanadi, et al. Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):369-74.

5,8-二羟基-1,4-萘醌物理化学性质

[ 密度 ]:
1.592g/cm3

[ 沸点 ]:
498.2ºC at 760mmHg

[ 熔点 ]:
220-230 °C(lit.)

[ 分子式 ]:
C₁₀H₆O₄

[ 分子量 ]:
190.15200

[ 闪点 ]:
269.2ºC

[ 精确质量 ]:
190.02700

[ PSA ]:
74.60000

[ LogP ]:
1.03300

[ 外观性状 ]:
暗紫色至棕色-黑色粉末

[ 蒸汽压 ]:
1.51E-10mmHg at 25°C

[ 折射率 ]:
1.71

[ 储存条件 ]:
室温

5,8-二羟基-1,4-萘醌MSDS

5,8-二羟基-1,4-萘醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL7970000

CHEMICAL NAME :: 1,4-Naphthoquinone, 5,8-dihydroxy-

CAS REGISTRY NUMBER :: 475-38-7

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H6-O4

MOLECULAR WEIGHT :: 190.16

WISWESSER LINE NOTATION :: L66 BV EVJ GQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,25,1983

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5,8-二羟基-1,4-萘醌安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25-S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QL7970000

[ 海关编码 ]:
2914690090

5,8-二羟基-1,4-萘醌合成路线

5,8-二羟基-1,4-萘醌上下游产品

5,8-二羟基-1,4-萘醌上游产品

5,8-二羟基-1,4-萘醌下游产品

5,8-二羟基-1,4-萘醌海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

5,8-二羟基-1,4-萘醌文献

Stimulation of Suicidal Erythrocyte Death by Naphthazarin.

Basic Clin Pharmacol Toxicol. 117 , 369-74, (2016)

The 1,4-naphthoquinone derivative naphthazarin may trigger apoptosis and is thus considered for the treatment of malignancy. On the other hand, naphthazarin decreases neurotoxicity. In analogy to apop...

Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

Bioorg. Med. Chem. 17 , 2276-81, (2009)

Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP-1 in particular ar...

Naphthazarin enhances ionizing radiation-induced cell cycle arrest and apoptosis in human breast cancer cells.

Int. J. Oncol. 46(4) , 1659-66, (2015)

Naphthazarin (Naph, DHNQ, 5,8-dihydroxy-l,4-naphthoquinone) is one of the naturally available 1,4-naphthoquinone derivatives that are well-known for their anti-inflammatory, antioxidant, antibacterial...

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