菲律平 III

菲律平 III用途

Filipin III 是 Filipin 的主要成分,Filipin 是一种 28-元环五烯大环内酯类抗真菌抗生素,由 S. filipinensis,S. avermitilis 和 S. miharaensis 产生。Filipin 可以与膜甾醇相互作用导致膜结构的改变。

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菲律平 III名称

[ CAS 号 ]:
480-49-9

[ 中文名 ]:
菲律平

[ 英文名 ]:
Filipin III

[中文别名 ]:

菲律宾菌素

[英文别名 ]:

Filipin III

菲律平 III生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

研究领域 >> 炎症/免疫

[ 靶点 ]

Fungal[1]

[参考文献]

[1]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

菲律平 III物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
913.9±65.0 °C at 760 mmHg

[ 熔点 ]:
163-180°C

[ 分子式 ]:
C₃₅H₅₈O₁₁

[ 分子量 ]:
654.828

[ 闪点 ]:
279.3±27.8 °C

[ 精确质量 ]:
654.397888

[ PSA ]:
208.37000

[ LogP ]:
-0.41

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
-20°C，密封，干燥，惰性气体

菲律平 III毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RN9800000

CHEMICAL NAME :: Oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, 4,6,8,10,12,14,16,27-octahydroxy-3- (1-hydroxyhexyl)-17,28-dimethyl-

CAS REGISTRY NUMBER :: 480-49-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C35-H58-O11

MOLECULAR WEIGHT :: 654.93

WISWESSER LINE NOTATION :: T-28-OV PU TU VU A&UTJ CYQ5 DQ FQ HQ JQ LQ MQ OQ P1 C&Q D&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

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菲律平 III安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
RN9800000

菲律平 III合成路线

详细合成路线

菲律平 III上下游产品

菲律平 III上游产品

菲律平 III下游产品

菲律平 III文献

Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.

PLoS ONE 8(2) , e55465, (2013)

We have previously shown that soluble collagen and a human pathogen, echovirus 1 (EV1) cluster α2β1 integrin on the plasma membrane and cause their internalization into cytoplasmic endosomes. Here we ...

Analysis of cholesterol trafficking with fluorescent probes.

Methods Cell Biol. 108 , 367-93, (2012)

Cholesterol plays an important role in determining the biophysical properties of biological membranes, and its concentration is tightly controlled by homeostatic processes. The intracellular transport...

Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4.

Biochem. Biophys. Res. Commun. 456(1) , 312-9, (2015)

TRPV4 is involved in several physiological and sensory functions as well as with several diseases and genetic disorders, though the molecular mechanisms for these are unclear. In this work we have ana...

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