菲律平 III

更新时间：2024-01-11 00:25:26

菲律平 III结构式	常用名	菲律平 III	英文名	Filipin III
	CAS号	480-49-9	分子量	654.828
	密度	1.2±0.1 g/cm3	沸点	913.9±65.0 °C at 760 mmHg
	分子式	C₃₅H₅₈O₁₁	熔点	163-180°C
	MSDS	中文版美版	闪点	279.3±27.8 °C
	符号	GHS07	信号词	Warning

菲律平 III用途

Filipin III 是 Filipin 的主要成分,Filipin 是一种 28-元环五烯大环内酯类抗真菌抗生素,由 S. filipinensis,S. avermitilis 和 S. miharaensis 产生。Filipin 可以与膜甾醇相互作用导致膜结构的改变。

中文名	菲律平
英文名	filipin III
中文别名	菲律宾菌素
英文别名	更多

描述	Filipin III 是 Filipin 的主要成分,Filipin 是一种 28-元环五烯大环内酯类抗真菌抗生素,由 S. filipinensis,S. avermitilis 和 S. miharaensis 产生。Filipin 可以与膜甾醇相互作用导致膜结构的改变。
相关类别	信号通路 >> 抗感染 >> 真菌研究领域 >> 炎症/免疫
靶点	Fungal[1]
参考文献	[1]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

密度	1.2±0.1 g/cm3
沸点	913.9±65.0 °C at 760 mmHg
熔点	163-180°C
分子式	C₃₅H₅₈O₁₁
分子量	654.828
闪点	279.3±27.8 °C
精确质量	654.397888
PSA	208.37000
LogP	-0.41
外观性状	固体
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.536
储存条件	-20°C，密封，干燥，惰性气体

菲律平 III毒性英文版

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xi
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	26-36
危险品运输编码	NONH for all modes of transport
RTECS号	RN9800000

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PLoS ONE 8(2) , e55465, (2013)

We have previously shown that soluble collagen and a human pathogen, echovirus 1 (EV1) cluster α2β1 integrin on the plasma membrane and cause their internalization into cytoplasmic endosomes. Here we ...

Analysis of cholesterol trafficking with fluorescent probes.

Methods Cell Biol. 108 , 367-93, (2012)

Cholesterol plays an important role in determining the biophysical properties of biological membranes, and its concentration is tightly controlled by homeostatic processes. The intracellular transport...

Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4.

Biochem. Biophys. Res. Commun. 456(1) , 312-9, (2015)

TRPV4 is involved in several physiological and sensory functions as well as with several diseases and genetic disorders, though the molecular mechanisms for these are unclear. In this work we have ana...

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Filipin III